Incidence of cytogenetic aberrations in two B lineage subpopulations in multiple myeloma patients analyzed by combination of whole-genome profiling and FISH

• Published in: Neoplasma Vol. 61; no. 1; p. 48
• Main Authors: Smetana, J, Dementyeva, E, Kryukov, F, Nemec, P, Greslikova, H, Kupska, R, Mikulasova, A, Ihnatova, I, Hajek, R, Kuglik, P
• Format: Journal Article
• Language: English
• Published: Slovakia 2014
• Subjects: Aged; Aged, 80 and over; Antigens, CD19 - analysis; Cell Lineage; Chromosome Aberrations; Comparative Genomic Hybridization; Female; Gene Dosage; Gene Rearrangement; Humans; Immunoglobulin Heavy Chains - genetics; In Situ Hybridization, Fluorescence - methods; Lymphocyte Subsets - immunology; Male; Middle Aged; Multiple Myeloma - genetics; Multiple Myeloma - immunology; Syndecan-1 - analysis

Multiple myeloma (MM) is an incurable malignant disease of the terminal developmental stage of B-lymphocytes. While genetic heterogeneity of MM is widely described, little is known about its genetic basis as well as primary damage during plasma cells (PC) development. In this study, we focused on ge...