Clinical Trials in Spinal Tumors: A Two-Decade Review
Clinical trials are essential for assessing the advancements in spine tumor therapeutics. The purpose of the present study was to characterize the trends in clinical trials for primary and metastatic tumor treatment during the past 2 decades. The ClinicalTrials.gov database was queried using the sea...
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Published in | World neurosurgery Vol. 161; pp. e39 - e53 |
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Elsevier Inc
01.05.2022
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Abstract | Clinical trials are essential for assessing the advancements in spine tumor therapeutics. The purpose of the present study was to characterize the trends in clinical trials for primary and metastatic tumor treatment during the past 2 decades.
The ClinicalTrials.gov database was queried using the search term “spine” for all interventional studies from 1999 to 2020 with the categories of “cancer,” “neoplasm,” “tumor,” and/or “metastasis.” The tumor type, phase data, enrollment numbers, and home institution country were recorded. The sponsor was categorized as an academic institution, industry, government, or other and the intervention type as procedure, drug, device, radiation therapy, or other. The frequency of each category and the cumulative frequency during the 20-year period were calculated.
A total of 106 registered trials for spine tumors were listed. All, except for 2, that had begun before 2008 had been completed. An enrollment of 51–100 participants (29.8%) was the most common, and most were phase II studies (54.4%). Most of the studies had examined metastatic tumors (58.5%), and the number of new trials annually had increased 3.4-fold from 2009 to 2020. Most of the studies had been conducted in the United States (56.4%). The most common intervention strategy was radiation therapy (32.1%), although from 2010 to 2020, procedural studies had become the most frequent (2.4/year). Most of the studies had been sponsored by academic institutions (63.2%), which during the 20-year period had sponsored 3.2-fold more studies compared with the industry partners.
The number of clinical trials for spine tumor therapies has rapidly increased during the past 15 years, owing to studies at U.S. academic medical institutions investigating radiosurgery for the treatment of metastases. Targeted therapies for tumor subtypes and sequelae have updated international best practices. |
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AbstractList | OBJECTIVEClinical trials are essential for assessing the advancements in spine tumor therapeutics. The purpose of the present study was to characterize the trends in clinical trials for primary and metastatic tumor treatment during the past 2 decades. METHODSThe ClinicalTrials.gov database was queried using the search term "spine" for all interventional studies from 1999 to 2020 with the categories of "cancer," "neoplasm," "tumor," and/or "metastasis." The tumor type, phase data, enrollment numbers, and home institution country were recorded. The sponsor was categorized as an academic institution, industry, government, or other and the intervention type as procedure, drug, device, radiation therapy, or other. The frequency of each category and the cumulative frequency during the 20-year period were calculated. RESULTSA total of 106 registered trials for spine tumors were listed. All, except for 2, that had begun before 2008 had been completed. An enrollment of 51-100 participants (29.8%) was the most common, and most were phase II studies (54.4%). Most of the studies had examined metastatic tumors (58.5%), and the number of new trials annually had increased 3.4-fold from 2009 to 2020. Most of the studies had been conducted in the United States (56.4%). The most common intervention strategy was radiation therapy (32.1%), although from 2010 to 2020, procedural studies had become the most frequent (2.4/year). Most of the studies had been sponsored by academic institutions (63.2%), which during the 20-year period had sponsored 3.2-fold more studies compared with the industry partners. CONCLUSIONSThe number of clinical trials for spine tumor therapies has rapidly increased during the past 15 years, owing to studies at U.S. academic medical institutions investigating radiosurgery for the treatment of metastases. Targeted therapies for tumor subtypes and sequelae have updated international best practices. Clinical trials are essential for assessing the advancements in spine tumor therapeutics. The purpose of the present study was to characterize the trends in clinical trials for primary and metastatic tumor treatment during the past 2 decades. The ClinicalTrials.gov database was queried using the search term “spine” for all interventional studies from 1999 to 2020 with the categories of “cancer,” “neoplasm,” “tumor,” and/or “metastasis.” The tumor type, phase data, enrollment numbers, and home institution country were recorded. The sponsor was categorized as an academic institution, industry, government, or other and the intervention type as procedure, drug, device, radiation therapy, or other. The frequency of each category and the cumulative frequency during the 20-year period were calculated. A total of 106 registered trials for spine tumors were listed. All, except for 2, that had begun before 2008 had been completed. An enrollment of 51–100 participants (29.8%) was the most common, and most were phase II studies (54.4%). Most of the studies had examined metastatic tumors (58.5%), and the number of new trials annually had increased 3.4-fold from 2009 to 2020. Most of the studies had been conducted in the United States (56.4%). The most common intervention strategy was radiation therapy (32.1%), although from 2010 to 2020, procedural studies had become the most frequent (2.4/year). Most of the studies had been sponsored by academic institutions (63.2%), which during the 20-year period had sponsored 3.2-fold more studies compared with the industry partners. The number of clinical trials for spine tumor therapies has rapidly increased during the past 15 years, owing to studies at U.S. academic medical institutions investigating radiosurgery for the treatment of metastases. Targeted therapies for tumor subtypes and sequelae have updated international best practices. |
Author | Chapman, Emily K. Caridi, John M. Shuman, William H. Gilligan, Jeffrey T. Gal, Jonathan S. Martini, Michael L. Yuk, Frank J. Schupper, Alexander J. Valliani, Aly A. Neifert, Sean N. |
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Cites_doi | 10.1016/S0140-6736(05)66954-1 10.1177/2192568219828727 10.1016/j.prro.2014.02.005 10.1002/cncr.31870 10.1093/neuros/nyw064 10.1097/00007632-200102150-00018 10.1007/s007010070018 10.1213/00000539-199612000-00028 10.1016/j.ejso.2020.04.028 10.1097/BRS.0000000000000112 10.5312/wjo.v7.i2.109 10.1097/BRS.0000000000002094 10.3171/2015.8.SPINE15674 10.1093/bja/65.2.237 10.3171/2015.11.SPINE15870 10.21037/atm.2019.04.41 |
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References | Murai, Murata, Manabe (bib10) 2014; 4 Bowdle, Camporesi, Maysick (bib15) 1996; 83 Barzilai, Versteeg, Sahgal (bib22) 2019; 125 Sharrock, Urquhart, Mineo (bib14) 1990; 65 Ahangar, Aziz, Rosenzweig, Weber (bib12) 2019; 7 (bib5) 1997 bib13 Charest-Morin, Fisher, Varga (bib21) 2017; 42 Patchell, Tibbs, Regine (bib2) 2005; 366 Charest-Morin, Fisher, Sahgal (bib3) 2019; 9 Radaelli, Fossati, Stacchiotti (bib24) 2020; 46 bib20 Çiftdemir, Kaya, Selcuk, Yalniz (bib1) 2016; 7 bib7 Mühlbauer, Pfisterer, Eyb, Knosp (bib9) 2000; 142 Woodard, Leon, Moriarty, Quinones, Zamani, Jolesz (bib16) 2001; 26 bib18 bib6 bib19 De la Garza-Ramos, Benvenutti-Regato, Caro-Osorio (bib8) 2016; 24 bib17 Dekutoski, Clarke, Rose (bib23) 2016; 25 Dea, Gokaslan, Choi, Fisher (bib4) 2017; 80 Korovessis, Vardakastanis, Vitsas, Syrimpeis (bib11) 2014; 39 Radaelli (10.1016/j.wneu.2021.11.101_bib24) 2020; 46 Murai (10.1016/j.wneu.2021.11.101_bib10) 2014; 4 Bowdle (10.1016/j.wneu.2021.11.101_bib15) 1996; 83 Woodard (10.1016/j.wneu.2021.11.101_bib16) 2001; 26 Patchell (10.1016/j.wneu.2021.11.101_bib2) 2005; 366 Çiftdemir (10.1016/j.wneu.2021.11.101_bib1) 2016; 7 De la Garza-Ramos (10.1016/j.wneu.2021.11.101_bib8) 2016; 24 Barzilai (10.1016/j.wneu.2021.11.101_bib22) 2019; 125 Charest-Morin (10.1016/j.wneu.2021.11.101_bib3) 2019; 9 Sharrock (10.1016/j.wneu.2021.11.101_bib14) 1990; 65 Mühlbauer (10.1016/j.wneu.2021.11.101_bib9) 2000; 142 Ahangar (10.1016/j.wneu.2021.11.101_bib12) 2019; 7 Dekutoski (10.1016/j.wneu.2021.11.101_bib23) 2016; 25 Korovessis (10.1016/j.wneu.2021.11.101_bib11) 2014; 39 Dea (10.1016/j.wneu.2021.11.101_bib4) 2017; 80 Charest-Morin (10.1016/j.wneu.2021.11.101_bib21) 2017; 42 |
References_xml | – volume: 366 start-page: 643 year: 2005 end-page: 648 ident: bib2 article-title: Direct decompressive surgical resection in the treatment of spinal cord compression caused by metastatic cancer: a randomised trial publication-title: Lancet contributor: fullname: Regine – ident: bib6 article-title: ClinicalTrials.gov identifier NCT00508443: evaluation of a novel CT-on-rails or trilogy stereotactic spine radiotherapy system (SSRS) – volume: 83 start-page: 1292 year: 1996 end-page: 1297 ident: bib15 article-title: A multicenter evaluation of remifentanil for early postoperative analgesia publication-title: Anesth Analg contributor: fullname: Maysick – year: 1997 ident: bib5 article-title: ClinicalTrials.gov. Bethesda, MD: U.S. National Library of Medicine – volume: 7 start-page: 223 year: 2019 ident: bib12 article-title: Advances in personalized treatment of metastatic spine disease publication-title: Ann Transl Med contributor: fullname: Weber – volume: 65 start-page: 237 year: 1990 end-page: 239 ident: bib14 article-title: Extradural anaesthesia in patients with previous lumbar spine surgery publication-title: Br J Anaesth contributor: fullname: Mineo – volume: 80 start-page: S124 year: 2017 end-page: S130 ident: bib4 article-title: Spine oncology—primary spine tumors publication-title: Neurosurgery contributor: fullname: Fisher – ident: bib7 article-title: ClinicalTrials.gov identifier NCT00855803: stereotactic body radiation therapy and vertebroplasty in treating patients with localized spinal metastasis – volume: 4 start-page: e231 year: 2014 end-page: e237 ident: bib10 article-title: Intensity modulated stereotactic body radiation therapy for single or multiple vertebral metastases with spinal cord compression publication-title: Pract Radiat Oncol contributor: fullname: Manabe – ident: bib17 article-title: ClinicalTrials.gov identifier NCT01254903: phase I study of feasibility of single session spine stereotactic radiosurgery (SSRS) in the primary management in patients with inoperable, previously unirradiated metastatic epidural spinal cord compression (MESCC) – volume: 9 start-page: 108S year: 2019 end-page: 116S ident: bib3 article-title: Primary bone tumor of the spine—an evolving field: what a general spine surgeon should know publication-title: Global Spine J contributor: fullname: Sahgal – ident: bib18 article-title: ClinicalTrials.gov identifier NCT02278744: trial for salvage re-irradiation of metastatic spine lesions using single-fraction stereotactic radiosurgery – volume: 46 start-page: 1415 year: 2020 end-page: 1422 ident: bib24 article-title: The sacral chordoma margin publication-title: Eur J Surg Oncol contributor: fullname: Stacchiotti – volume: 39 start-page: E231 year: 2014 end-page: E239 ident: bib11 article-title: Is Kiva implant advantageous to balloon kyphoplasty in treating osteolytic metastasis to the spine? Comparison of 2 percutaneous minimal invasive spine techniques: a prospective randomized controlled short-term study publication-title: Spine (Phila Pa 1976) contributor: fullname: Syrimpeis – volume: 42 start-page: 1383 year: 2017 end-page: 1390 ident: bib21 article-title: En bloc resection versus intralesional surgery in the treatment of giant cell tumor of the spine publication-title: Spine (Phila Pa 1976) contributor: fullname: Varga – volume: 24 start-page: 810 year: 2016 end-page: 823 ident: bib8 article-title: The 100 most-cited articles in spinal oncology publication-title: J Neurosurg Spine contributor: fullname: Caro-Osorio – volume: 25 start-page: 59 year: 2016 end-page: 68 ident: bib23 article-title: Osteosarcoma of the spine: prognostic variables for local recurrence and overall survival, a multicenter ambispective study publication-title: J Neurosurg Spine contributor: fullname: Rose – volume: 142 start-page: 1219 year: 2000 end-page: 1230 ident: bib9 article-title: Noncontiguous spinal metastases and plasmocytomas should be operated on through a single posterior midline approach, and circumferential decompression should be performed with individualized reconstruction publication-title: Acta Neurochir (Wien) contributor: fullname: Knosp – ident: bib13 article-title: ClinicalTrials.gov identifier NCT02387905: cement augmentation in preventing vertebral body compression fracture following spine stereotactic radiosurgery in patients with solid tumors and spinal metastases – ident: bib20 article-title: ClinicalTrials.gov identifier NCT00211237: CAFE study - cancer patient fracture evaluation (CAFE) – volume: 26 start-page: 410 year: 2001 end-page: 417 ident: bib16 article-title: Initial experience with intraoperative magnetic resonance imaging in spine surgery publication-title: Spine (Phila Pa 1976) contributor: fullname: Jolesz – volume: 7 start-page: 109 year: 2016 end-page: 116 ident: bib1 article-title: Tumors of the spine publication-title: World J Orthop contributor: fullname: Yalniz – volume: 125 start-page: 770 year: 2019 end-page: 778 ident: bib22 article-title: Survival, local control, and health-related quality of life in patients with oligometastatic and polymetastatic spinal tumors: a multicenter, international study publication-title: Cancer contributor: fullname: Sahgal – ident: bib19 article-title: ClinicalTrials.gov identifier NCT03249584: OsteoCool tumor ablation post-market study (OPuS One) – volume: 366 start-page: 643 year: 2005 ident: 10.1016/j.wneu.2021.11.101_bib2 article-title: Direct decompressive surgical resection in the treatment of spinal cord compression caused by metastatic cancer: a randomised trial publication-title: Lancet doi: 10.1016/S0140-6736(05)66954-1 contributor: fullname: Patchell – volume: 9 start-page: 108S issue: suppl year: 2019 ident: 10.1016/j.wneu.2021.11.101_bib3 article-title: Primary bone tumor of the spine—an evolving field: what a general spine surgeon should know publication-title: Global Spine J doi: 10.1177/2192568219828727 contributor: fullname: Charest-Morin – volume: 4 start-page: e231 year: 2014 ident: 10.1016/j.wneu.2021.11.101_bib10 article-title: Intensity modulated stereotactic body radiation therapy for single or multiple vertebral metastases with spinal cord compression publication-title: Pract Radiat Oncol doi: 10.1016/j.prro.2014.02.005 contributor: fullname: Murai – volume: 125 start-page: 770 year: 2019 ident: 10.1016/j.wneu.2021.11.101_bib22 article-title: Survival, local control, and health-related quality of life in patients with oligometastatic and polymetastatic spinal tumors: a multicenter, international study publication-title: Cancer doi: 10.1002/cncr.31870 contributor: fullname: Barzilai – volume: 80 start-page: S124 issue: suppl year: 2017 ident: 10.1016/j.wneu.2021.11.101_bib4 article-title: Spine oncology—primary spine tumors publication-title: Neurosurgery doi: 10.1093/neuros/nyw064 contributor: fullname: Dea – volume: 26 start-page: 410 year: 2001 ident: 10.1016/j.wneu.2021.11.101_bib16 article-title: Initial experience with intraoperative magnetic resonance imaging in spine surgery publication-title: Spine (Phila Pa 1976) doi: 10.1097/00007632-200102150-00018 contributor: fullname: Woodard – volume: 142 start-page: 1219 year: 2000 ident: 10.1016/j.wneu.2021.11.101_bib9 article-title: Noncontiguous spinal metastases and plasmocytomas should be operated on through a single posterior midline approach, and circumferential decompression should be performed with individualized reconstruction publication-title: Acta Neurochir (Wien) doi: 10.1007/s007010070018 contributor: fullname: Mühlbauer – volume: 83 start-page: 1292 year: 1996 ident: 10.1016/j.wneu.2021.11.101_bib15 article-title: A multicenter evaluation of remifentanil for early postoperative analgesia publication-title: Anesth Analg doi: 10.1213/00000539-199612000-00028 contributor: fullname: Bowdle – volume: 46 start-page: 1415 year: 2020 ident: 10.1016/j.wneu.2021.11.101_bib24 article-title: The sacral chordoma margin publication-title: Eur J Surg Oncol doi: 10.1016/j.ejso.2020.04.028 contributor: fullname: Radaelli – volume: 39 start-page: E231 year: 2014 ident: 10.1016/j.wneu.2021.11.101_bib11 article-title: Is Kiva implant advantageous to balloon kyphoplasty in treating osteolytic metastasis to the spine? Comparison of 2 percutaneous minimal invasive spine techniques: a prospective randomized controlled short-term study publication-title: Spine (Phila Pa 1976) doi: 10.1097/BRS.0000000000000112 contributor: fullname: Korovessis – volume: 7 start-page: 109 year: 2016 ident: 10.1016/j.wneu.2021.11.101_bib1 article-title: Tumors of the spine publication-title: World J Orthop doi: 10.5312/wjo.v7.i2.109 contributor: fullname: Çiftdemir – volume: 42 start-page: 1383 year: 2017 ident: 10.1016/j.wneu.2021.11.101_bib21 article-title: En bloc resection versus intralesional surgery in the treatment of giant cell tumor of the spine publication-title: Spine (Phila Pa 1976) doi: 10.1097/BRS.0000000000002094 contributor: fullname: Charest-Morin – volume: 24 start-page: 810 year: 2016 ident: 10.1016/j.wneu.2021.11.101_bib8 article-title: The 100 most-cited articles in spinal oncology publication-title: J Neurosurg Spine doi: 10.3171/2015.8.SPINE15674 contributor: fullname: De la Garza-Ramos – volume: 65 start-page: 237 year: 1990 ident: 10.1016/j.wneu.2021.11.101_bib14 article-title: Extradural anaesthesia in patients with previous lumbar spine surgery publication-title: Br J Anaesth doi: 10.1093/bja/65.2.237 contributor: fullname: Sharrock – volume: 25 start-page: 59 year: 2016 ident: 10.1016/j.wneu.2021.11.101_bib23 article-title: Osteosarcoma of the spine: prognostic variables for local recurrence and overall survival, a multicenter ambispective study publication-title: J Neurosurg Spine doi: 10.3171/2015.11.SPINE15870 contributor: fullname: Dekutoski – volume: 7 start-page: 223 year: 2019 ident: 10.1016/j.wneu.2021.11.101_bib12 article-title: Advances in personalized treatment of metastatic spine disease publication-title: Ann Transl Med doi: 10.21037/atm.2019.04.41 contributor: fullname: Ahangar |
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Snippet | Clinical trials are essential for assessing the advancements in spine tumor therapeutics. The purpose of the present study was to characterize the trends in... OBJECTIVEClinical trials are essential for assessing the advancements in spine tumor therapeutics. The purpose of the present study was to characterize the... |
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SubjectTerms | Clinical trial Clinical Trials as Topic Databases, Factual Humans Metastasis Radiosurgery Spinal Neoplasms - surgery Spine Tumor United States |
Title | Clinical Trials in Spinal Tumors: A Two-Decade Review |
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