Eye Movements and the Intraorbital Subarachnoid Space: Potential Contribution of Altered Cerebrospinal Fluid Pumping in Optic Neuropathies

• Published in: Investigative ophthalmology & visual science Vol. 66; no. 1; p. 53
• Main Authors: Demer, Joseph L., Clark, Robert A., Suh, Soh Youn, Giaconi, JoAnn A., Nouri-Mahdavi, Kouros, Law, Simon K., Bonelli, Laura, Arnold, Anthony C., Quiros, Peter, Coleman, Anne L., Caprioli, Joseph
• Format: Journal Article
• Language: English
• Published: United States 02.01.2025
• Subjects: Adult; Aged; Cerebrospinal Fluid - physiology; Cerebrospinal Fluid Pressure - physiology; Eye Movements - physiology; Female; Glaucoma, Open-Angle - physiopathology; Humans; Intraocular Pressure - physiology; Magnetic Resonance Imaging; Male; Middle Aged; Optic Nerve - pathology; Optic Nerve Diseases - physiopathology; Optic Neuropathy, Ischemic - physiopathology; Orbit; Subarachnoid Space - physiopathology

The optic nerve (ON) is mechanically perturbed by eye movements that shift cerebrospinal fluid (CSF) within its surrounding dural sheath. This study compared changes in ON length and CSF volume within the intraorbital ON sheath caused by eye movements in healthy subjects and patients with optic neur...