Detection of Mitotic Neuroblasts Provides Additional Evidence of Steady-State Neurogenesis in the Adult Small Intestinal Myenteric Plexus

• Published in: eNeuro Vol. 12; no. 3; p. ENEURO.0005-24.2025
• Main Authors: Gorecki, Anastazja M., Slosberg, Jared, Hong, Su Min, Seika, Philippa, Puttapaka, Srinivas N., Migden, Blake, Gulko, Anton, Singh, Alpana, Zhang, Chengxiu, Gurumurthy, Rohin, Kulkarni, Subhash
• Format: Journal Article
• Language: English
• Published: United States Society for Neuroscience 01.03.2025
• Subjects: Adult; Animals; ELAV-Like Protein 3 - metabolism; Female; Histones - metabolism; Humans; Intestine, Small - cytology; Intestine, Small - innervation; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mitosis - physiology; Myenteric Plexus - cytology; Neural Stem Cells - cytology; Neural Stem Cells - physiology; Neurogenesis - physiology; Neurons - cytology; New Research; adult neurogenesis; flow analyses; enteric nervous system; DNA content; phosphor-histone H3; neuroblasts

Maintenance of normal structure of the enteric nervous system (ENS), which regulates key gastrointestinal functions, requires robust homeostatic mechanisms, since by virtue of its location within the gut wall, the ENS is subject to constant mechanical, chemical, and biological stressors. Using trans...