Organocatalytic tandem three-component reaction of aldehyde, alkyl vinyl ketone, and amide: one-pot syntheses of highly functional alkenes

• Published in: Organic & biomolecular chemistry Vol. 9; no. 2; pp. 363 - 366
• Main Authors: Wang, De-Wei, Syu, Siang-en, Hung, Yi-Ting, Chen, Pei-yi, Lee, Chia-Jui, Chen, Ko-Wei, Chen, Yu-Jhang, Lin, Wenwei
• Format: Journal Article
• Language: English
• Published: CAMBRIDGE Royal Soc Chemistry 21.01.2011
• Subjects: Chemistry; Chemistry, Organic; Physical Sciences; Science & Technology; BAYLIS-HILLMAN REACTION; CHEMISTRY; MULTICOMPONENT REACTIONS

An EtPPh2-or PPh3-catalyzed tandem three-component reaction of aldehyde, alkyl vinyl ketone, and amide is developed. Its further application in one-pot syntheses of highly functional alkenes starting from aldehydes, alkyl vinyl ketones, and amides is realized. A wide variety of highly functional alp...