Nonstabilized SARS-CoV-2 spike mRNA vaccination induces broadly neutralizing antibodies in nonhuman primates

• Published in: Science translational medicine Vol. 17; no. 802; p. eadn5651
• Main Authors: Malewana, R Dilshan, Stalls, Victoria, May, Aaron, Lu, Xiaozhi, Martinez, David R, Schäfer, Alexandra, Li, Dapeng, Barr, Maggie, Sutherland, Laura L, Lee, Esther, Parks, Robert, Beck, Whitney Edwards, Newman, Amanda, Bock, Kevin W, Minai, Mahnaz, Nagata, Bianca M, DeMarco, C Todd, Denny, Thomas N, Oguin, 3rd, Thomas H, Rountree, Wes, Wang, Yunfei, Mansouri, Katayoun, Edwards, Robert J, Smith, Lena, Sempowski, Gregory D, Eaton, Amanda, Muramatsu, Hiromi, Henderson, Rory, Tam, Ying, Barbosa, Christopher, Tang, Juanjie, Cain, Derek W, Santra, Sampa, Moore, Ian N, Andersen, Hanne, Lewis, Mark G, Golding, Hana, Seder, Robert, Khurana, Surender, Montefiori, David C, Pardi, Norbert, Weissman, Drew, Baric, Ralph S, Acharya, Priyamvada, Haynes, Barton F, Saunders, Kevin O
• Format: Journal Article
• Language: English
• Published: United States 11.06.2025
• Subjects: Animals; Antibodies, Neutralizing - immunology; Antibodies, Viral - immunology; Broadly Neutralizing Antibodies - immunology; COVID-19 - immunology; COVID-19 - prevention & control; COVID-19 - virology; COVID-19 Vaccines - immunology; Humans; Macaca mulatta; mRNA Vaccines - immunology; RNA, Messenger - genetics; RNA, Messenger - immunology; SARS-CoV-2 - genetics; SARS-CoV-2 - immunology; Spike Glycoprotein, Coronavirus - chemistry; Spike Glycoprotein, Coronavirus - genetics; Spike Glycoprotein, Coronavirus - immunology; Vaccination

Immunization with messenger RNA (mRNA) or viral vectors encoding spike protein with diproline substitutions (S-2P) were shown to provide protective immunity, curbing the COVID-19 pandemic. However, in light of the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of...