Brominated bitter compounds from the skin tubercle gland of the stonefish Synanceia verrucosa

• Published in: Bioscience, biotechnology, and biochemistry Vol. 89; no. 9; pp. 1257 - 1263
• Main Authors: Kawabe, Ryoya, Hoshi, Sota, Hifumi, Toru, Yamamoto, Akihiko, Uchida, Hajime, Satake, Masayuki, Nagai, Hiroshi
• Format: Journal Article
• Language: English
• Published: England 23.08.2025
• Subjects: Animals; Fishes - metabolism; Halogenation; Mice; Skin - chemistry; Skin - metabolism; Taste; ichthyocrinotoxin; stonefish; marine natural product; skin tubercle gland; bitterness

The skin tubercle gland of the stonefish Synanceia verrucosa secretes “ichthyocrinotoxin.” Ichthyocrinotoxins have been suggested to act as antifeedants against predators and as anthelmintics against parasites. Three novel compounds, synanceins A (1), B (2), and C (3), were isolated from S. verrucos...