Aspergillus fumigatus causes in vitro electrophysiological and morphological modifications in human nasal epithelial cells

• Published in: Histology and histopathology Vol. 17; no. 4; p. 1095
• Main Authors: Botterel, F, Cordonnier, C, Barbier, V, Wingerstmann, L, Liance, M, Coste, A, Escudier, E, Bretagne, S
• Format: Journal Article
• Language: English
• Published: Spain 01.10.2002
• Subjects: Amiloride - pharmacology; Aspergillosis - pathology; Aspergillosis - physiopathology; Aspergillus fumigatus; Aspergillus niger; Cells, Cultured; Diuretics - pharmacology; Electrophysiology; Epithelial Cells - pathology; Humans; Microscopy, Electron; Nasal Mucosa - pathology; Nasal Mucosa - physiopathology; Nasal Polyps - pathology; Nasal Polyps - physiopathology; Penicillium chrysogenum

The role of the airway epithelium in the development of invasive aspergillosis in immunocompromised hosts has rarely been studied although patients at risk for this infection frequently have epithelial damage. We developed an in vitro model of primary culture of human nasal epithelial cells (HNEC) i...