Copper complex species within a fragment of the N-terminal repeat region in opossum PrP protein

• Published in: Dalton transactions : an international journal of inorganic chemistry Vol. 40; no. 11; pp. 2441 - 2450
• Main Authors: Vagliasindi, Laura I, Arena, Giuseppe, Bonomo, Raffaele P, Pappalardo, Giuseppe, Tabbì, Giovanni
• Format: Journal Article
• Language: English
• Published: England 21.03.2011
• Subjects: Animals; Chromatography, High Pressure Liquid - instrumentation; Chromatography, High Pressure Liquid - methods; Circular Dichroism; Copper - chemistry; Electron Spin Resonance Spectroscopy; Humans; Opossums; Potentiometry; Prions - chemistry; Prions - genetics; Spectrum Analysis - methods

A spectroscopic (UV-Vis, CD and EPR), thermodynamic and voltammetric study of the copper(ii) complexes with the Ac-PHPGGSNWGQ-NH(2) polypeptide (L), a fragment of the opossum PrP protein N-terminal four-repeat region, was carried out in aqueous solution. It suggests the formation of a highly distort...