Guanidinoacetic acid attenuates high-fat diet induced colitis by targeting mitophagy and the gut microbiota in middle-aged mice

• Published in: Food bioscience Vol. 68; p. 106587
• Main Authors: Zhao, Jiamin, Ji, Bingzhen, Li, Xvying, Zhang, Weipeng, Zhao, Junxing
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 01.06.2025
• Subjects: chemokines; Colitis; colon; Guanidinoacetic acid; High fat diet; inflammation; interleukin-6; intestinal microorganisms; Microbiota; Mitophagy; necrosis; neoplasms; Obesity; protein synthesis; tight junctions; transcription factor NF-kappa B; Guanidinoacetic acid; Obesity; Microbiota; Colitis; Mitophagy; High fat diet

The increasing incidence of obesity has been associated with various diseases, including inflammatory bowel disease. Guanidinoacetic acid (GAA) regulated various crucial physiological processes. The present study aimed to determine the action of dietary GAA on high-fat diet (HFD)-induced colitis in...