Chromogranin A in human neuroendocrine tumors: an immunohistochemical study with region-specific antibodies

• Published in: The American journal of surgical pathology Vol. 25; no. 10; p. 1261
• Main Authors: Portel-Gomes, G M, Grimelius, L, Johansson, H, Wilander, E, Stridsberg, M
• Format: Journal Article
• Language: English
• Published: United States 01.10.2001
• Subjects: Adenoma - metabolism; Adenoma - pathology; Bronchial Neoplasms - metabolism; Bronchial Neoplasms - pathology; Carcinoid Tumor - metabolism; Carcinoid Tumor - pathology; Carcinoma, Medullary - metabolism; Carcinoma, Medullary - pathology; Chromogranin A; Chromogranins - classification; Chromogranins - immunology; Chromogranins - metabolism; Digestive System Neoplasms - metabolism; Digestive System Neoplasms - pathology; Endocrine Gland Neoplasms - metabolism; Endocrine Gland Neoplasms - pathology; Humans; Immunohistochemistry; Insulinoma - metabolism; Insulinoma - pathology; Pheochromocytoma - metabolism; Pheochromocytoma - pathology

Antibodies to six specific regions of the chromogranin A (CgA) molecule were used to study their immunoreactivity in human neuroendocrine (NE) tumors. Tissue specimens from endocrine pancreatic tumors (n = 14), duodenal carcinoids (n = 2), bronchial carcinoids (n = 5), ileal carcinoids (n = 5) appen...