Changes in plasma levels of ghrelin, leptin, and other hormonal and metabolic parameters following standardized breakfast, lunch, and physical exercise before and after a multidisciplinary weight-reduction intervention in obese adolescents
Objective : To investigate in severely obese adolescents the effects of a 3-week multidisciplinary weight-reduction intervention involving moderate energy restriction, individualised physical activity and behavior therapy on the response of some hormonal and metabolic parameters to meals and exercis...
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Published in | Journal of endocrinological investigation Vol. 33; no. 9; pp. 633 - 639 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
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Springer International Publishing
01.10.2010
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Abstract | Objective
: To investigate in severely obese adolescents the effects of a 3-week multidisciplinary weight-reduction intervention involving moderate energy restriction, individualised physical activity and behavior therapy on the response of some hormonal and metabolic parameters to meals and exercise.
Design
: Clinical longitudinal study on inpatients in a specialised institution. Subjects: A total of 20 obese adolescents (10 boys and 10 girls) aged 12–17 yr [body mass index (BMI): 37.7±6.1 kg/m
2
; fat mass (FM): 44.8±13.2 kg].
Measurements
: The changes in plasma concentration of leptin, ghrelin, GH, IGF-I, insulin, glucose, and non-esterified fatty acids (NEFA) in response to standardised meals and exercise bouts were measured before and after the weight-reduction intervention. At the same times, body composition was assessed by bioelectrical impedance as well as appetite sensations using a visual analog scale.
Results
: At the end of the intervention, the adolescents had lost body weight and FM (expressed both in kg and %) (
p
<0.05), without any significant fat-free mass loss (in % terms). In response to both meals and exercise, after the 3-week intervention, plasma leptin concentration decreased significantly (
p
<0.05), whereas the other hormones (insulin, ghrelin, GH, and IGF-I) and metabolic parameters (glucose and NEFA) did not change. Interestingly, appetite was not affected by the intervention.
Conclusion
: This 3-week multidisciplinary intervention in obese adolescents induced a significant body weight loss with beneficial changes in body composition. However, despite there being no change in metabolic parameters and ghrelin in response to meals and exercise after the intervention, plasma concentrations of leptin were decreased. The failure of ghrelin levels to increase by this approach might explain the good control of appetite observed at the end of the study. |
---|---|
AbstractList | Objective
: To investigate in severely obese adolescents the effects of a 3-week multidisciplinary weight-reduction intervention involving moderate energy restriction, individualised physical activity and behavior therapy on the response of some hormonal and metabolic parameters to meals and exercise.
Design
: Clinical longitudinal study on inpatients in a specialised institution. Subjects: A total of 20 obese adolescents (10 boys and 10 girls) aged 12–17 yr [body mass index (BMI): 37.7±6.1 kg/m
2
; fat mass (FM): 44.8±13.2 kg].
Measurements
: The changes in plasma concentration of leptin, ghrelin, GH, IGF-I, insulin, glucose, and non-esterified fatty acids (NEFA) in response to standardised meals and exercise bouts were measured before and after the weight-reduction intervention. At the same times, body composition was assessed by bioelectrical impedance as well as appetite sensations using a visual analog scale.
Results
: At the end of the intervention, the adolescents had lost body weight and FM (expressed both in kg and %) (
p
<0.05), without any significant fat-free mass loss (in % terms). In response to both meals and exercise, after the 3-week intervention, plasma leptin concentration decreased significantly (
p
<0.05), whereas the other hormones (insulin, ghrelin, GH, and IGF-I) and metabolic parameters (glucose and NEFA) did not change. Interestingly, appetite was not affected by the intervention.
Conclusion
: This 3-week multidisciplinary intervention in obese adolescents induced a significant body weight loss with beneficial changes in body composition. However, despite there being no change in metabolic parameters and ghrelin in response to meals and exercise after the intervention, plasma concentrations of leptin were decreased. The failure of ghrelin levels to increase by this approach might explain the good control of appetite observed at the end of the study. To investigate in severely obese adolescents the effects of a 3-week multidisciplinary weight-reduction intervention involving moderate energy restriction, individualised physical activity and behavior therapy on the response of some hormonal and metabolic parameters to meals and exercise. Clinical longitudinal study on inpatients in a specialised institution. A total of 20 obese adolescents (10 boys and 10 girls) aged 12-17 yr [body mass index (BMI): 37.7±6.1 kg/m2; fat mass (FM): 44.8±13.2 kg]. The changes in plasma concentration of leptin, ghrelin, GH, IGF-I, insulin, glucose, and non-esterified fatty acids (NEFA) in response to standardised meals and exercise bouts were measured before and after the weight-reduction intervention. At the same times, body composition was assessed by bioelectrical impedance as well as appetite sensations using a visual analog scale. At the end of the intervention, the adolescents had lost body weight and FM (expressed both in kg and %) (p<0.05), without any significant fat-free mass loss (in % terms). In response to both meals and exercise, after the 3-week intervention, plasma leptin concentration decreased significantly (p<0.05), whereas the other hormones (insulin, ghrelin, GH, and IGF-I) and metabolic parameters (glucose and NEFA) did not change. Interestingly, appetite was not affected by the intervention. This 3-week multidisciplinary intervention in obese adolescents induced a significant body weight loss with beneficial changes in body composition. However, despite there being no change in metabolic parameters and ghrelin in response to meals and exercise after the intervention, plasma concentrations of leptin were decreased. The failure of ghrelin levels to increase by this approach might explain the good control of appetite observed at the end of the study. |
Author | Agosti, F. Cella, S. G. Rigamonti, A. E. Lafortuna, C. L. Muller, E. E. Marazzi, N. Sartorio, A. De Col, A. |
Author_xml | – sequence: 1 givenname: A. E. surname: Rigamonti fullname: Rigamonti, A. E. organization: Department of Medical Pharmacology, University of Milan – sequence: 2 givenname: F. surname: Agosti fullname: Agosti, F. organization: Laboratorio Sperimentale di Ricerche Endocrinologiche (LSRE), Istituto Auxologico Italiano, IRCCS – sequence: 3 givenname: A. surname: De Col fullname: De Col, A. organization: Laboratorio Sperimentale di Ricerche Endocrinologiche (LSRE), Istituto Auxologico Italiano, IRCCS – sequence: 4 givenname: N. surname: Marazzi fullname: Marazzi, N. organization: Laboratorio Sperimentale di Ricerche Endocrinologiche (LSRE), Istituto Auxologico Italiano, IRCCS – sequence: 5 givenname: C. L. surname: Lafortuna fullname: Lafortuna, C. L. organization: Istituto di Bioimmagini e Fisiologia Molecolare del Consiglio Nazionale delle Ricerche – sequence: 6 givenname: S. G. surname: Cella fullname: Cella, S. G. organization: Department of Medical Pharmacology, University of Milan – sequence: 7 givenname: E. E. surname: Muller fullname: Muller, E. E. organization: Department of Medical Pharmacology, University of Milan – sequence: 8 givenname: A. surname: Sartorio fullname: Sartorio, A. email: sartorio@auxologico.it organization: Laboratorio Sperimentale di Ricerche Endocrinologiche (LSRE), Istituto Auxologico Italiano, IRCCS |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/20339311$$D View this record in MEDLINE/PubMed |
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CitedBy_id | crossref_primary_10_1016_j_appet_2016_09_032 crossref_primary_10_1016_j_metabol_2011_10_015 crossref_primary_10_1210_clinem_dgz046 crossref_primary_10_3390_ijerph19031480 crossref_primary_10_1186_2050_2974_2_7 crossref_primary_10_1210_jc_2013_4010 crossref_primary_10_1007_BF03346710 crossref_primary_10_1016_j_nut_2022_111815 crossref_primary_10_1016_j_peptides_2015_06_007 crossref_primary_10_1016_j_physbeh_2011_08_014 crossref_primary_10_1158_1055_9965_EPI_13_1053 |
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Keywords | weight loss ghrelin leptin obesity Adolescent |
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: To investigate in severely obese adolescents the effects of a 3-week multidisciplinary weight-reduction intervention involving moderate energy... To investigate in severely obese adolescents the effects of a 3-week multidisciplinary weight-reduction intervention involving moderate energy restriction,... |
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SubjectTerms | Adolescent Child Combined Modality Therapy - methods Eating - physiology Endocrinology Exercise - physiology Female Ghrelin - blood Humans Interdisciplinary Communication Leptin - blood Male Medicine Medicine & Public Health Metabolic Diseases Obesity - blood Obesity - metabolism Obesity - therapy Peptide Hormones - blood Rapid Communication Reference Standards Weight Loss - physiology |
Title | Changes in plasma levels of ghrelin, leptin, and other hormonal and metabolic parameters following standardized breakfast, lunch, and physical exercise before and after a multidisciplinary weight-reduction intervention in obese adolescents |
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