Recent advances in the molecular pharmacology of the α1-adrenergic receptors

This review is intended to discuss recent developments in the molecular pharmacology of the α 1-adrenergic receptor ( α 1-AR) subtypes. After a brief historical development will focus on the more contemporary issues having to do with this receptor family. Emphasis will be put on recent data regardin...

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Bibliographic Details
Published inCellular Signalling Vol. 8; no. 5; pp. 323 - 333
Main Authors Guarino, Richard D., Perez, Dianne M., Piascik, Michael T.
Format Book Review Journal Article
LanguageEnglish
Published Elsevier Inc 01.08.1996
Subjects
review
α1-adrenergic receptors
CEC
RT
bps
PMA
PKC
α 1-adrenergic receptors
mRNA
cAMP
H7
RNAse
AR
review
CAT
kb
5-MU
TM
ARTF
PCR
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Summary:This review is intended to discuss recent developments in the molecular pharmacology of the α 1-adrenergic receptor ( α 1-AR) subtypes. After a brief historical development will focus on the more contemporary issues having to do with this receptor family. Emphasis will be put on recent data regarding the cloning, nomenclature, signalling mechanisms, and genomic organization of the α 1-AR subtypes. We will also highlight recent mutational studies that identify key amino acid residues involved in ligand binding, as well as the role of the α 1-AR subtypes in regulating physiologic processes.
ISSN:0898-6568
1873-3913
DOI:10.1016/0898-6568(96)00066-6