A placebo-controlled randomized clinical trial of antibiotics versus probiotics as an adjuvant to nonsurgical periodontal treatment among smokers with Stage III, Grade C generalized periodontitis
Probiotics are viable microorganisms, which if delivered in appropriate dose can provide health benefits. Lactobacillus reuteri (DM17938+ATCC PTA 5289) has been recommended as a safe choice for probiotics. The objective of this study is to compare the improvement in the periodontal parameters amongs...
Saved in:
Published in | Clinical advances in periodontics |
---|---|
Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
01.09.2023
|
Subjects | |
Online Access | Get more information |
Cover
Loading…
Abstract | Probiotics are viable microorganisms, which if delivered in appropriate dose can provide health benefits. Lactobacillus reuteri (DM17938+ATCC PTA 5289) has been recommended as a safe choice for probiotics. The objective of this study is to compare the improvement in the periodontal parameters amongst smokers with generalized periodontitis with Stage III, Grade C treated with nonsurgical periodontal treatment (NSPT) to which either an antibiotics or probiotics were given as an adjuvant.
Sixty smokers with Stage III, Grade C generalized periodontitis were randomized in two groups after taking informed consent. Periodontal parameters including bleeding on probing (BOP), probing depth (PD), attachment loss (AL), gingival index (GI), and plaque index (PI) were recorded. Group 1 received (after NSPT and oral hygiene instructions) amoxicillin and metronidazole for 7 days and a placebo for probiotics for 30 days. Group 2 was provided (after NSPT and oral hygiene instructions) with one tablet of Lactobacillus reuteri probiotics (2 × 10
CFU) twice daily for 30 days and placebo antibiotics for 7 days. The periodontal parameters were recorded again at 1- and 3-month follow-ups as outcome variables. Mean, standard deviation, and confidence interval were reported using SPSS 20.0.
A statistically significant clinical improvement in the PD, BOP, PI, and GI were observed in both the groups at 3-month follow-up. However, the AL remained unchanged in both the groups.
Administration of probiotics and antibiotics along with NSPT yield statistically significant differences in PD and BOP from baseline to 3-month follow-up. However, between the group differences were not statistically significant for the periodontal parameters (AL, PD, and BOP). |
---|---|
AbstractList | Probiotics are viable microorganisms, which if delivered in appropriate dose can provide health benefits. Lactobacillus reuteri (DM17938+ATCC PTA 5289) has been recommended as a safe choice for probiotics. The objective of this study is to compare the improvement in the periodontal parameters amongst smokers with generalized periodontitis with Stage III, Grade C treated with nonsurgical periodontal treatment (NSPT) to which either an antibiotics or probiotics were given as an adjuvant.
Sixty smokers with Stage III, Grade C generalized periodontitis were randomized in two groups after taking informed consent. Periodontal parameters including bleeding on probing (BOP), probing depth (PD), attachment loss (AL), gingival index (GI), and plaque index (PI) were recorded. Group 1 received (after NSPT and oral hygiene instructions) amoxicillin and metronidazole for 7 days and a placebo for probiotics for 30 days. Group 2 was provided (after NSPT and oral hygiene instructions) with one tablet of Lactobacillus reuteri probiotics (2 × 10
CFU) twice daily for 30 days and placebo antibiotics for 7 days. The periodontal parameters were recorded again at 1- and 3-month follow-ups as outcome variables. Mean, standard deviation, and confidence interval were reported using SPSS 20.0.
A statistically significant clinical improvement in the PD, BOP, PI, and GI were observed in both the groups at 3-month follow-up. However, the AL remained unchanged in both the groups.
Administration of probiotics and antibiotics along with NSPT yield statistically significant differences in PD and BOP from baseline to 3-month follow-up. However, between the group differences were not statistically significant for the periodontal parameters (AL, PD, and BOP). |
Author | Ahmed, Shahbaz Khan, Farhan Raza Farooqui, Waqas Ahmed Akber, Ather Khalid, Fizza Ghazal, Mehwish Shabbir, Sumaiya Sadiq, Ali Riaz, Sania |
Author_xml | – sequence: 1 givenname: Mehwish surname: Ghazal fullname: Ghazal, Mehwish organization: Department of Periodontology, Dow University of Health Sciences, Karachi, Pakistan – sequence: 2 givenname: Shahbaz surname: Ahmed fullname: Ahmed, Shahbaz organization: Department of Operative Dentistry, Dr. Ishratul Ebad Khan Institute of Oral Health Sciences, Karachi, Pakistan – sequence: 3 givenname: Waqas Ahmed surname: Farooqui fullname: Farooqui, Waqas Ahmed organization: Department of Research, Dow University of Health Sciences, Karachi, Pakistan – sequence: 4 givenname: Fizza surname: Khalid fullname: Khalid, Fizza organization: Department of Periodontology, Baqai Dental College, Karachi, Pakistan – sequence: 5 givenname: Sania surname: Riaz fullname: Riaz, Sania organization: Department of Periodontology, Baqai Dental College, Karachi, Pakistan – sequence: 6 givenname: Ather surname: Akber fullname: Akber, Ather organization: Department of Periodontology, Dow University of Health Sciences, Karachi, Pakistan – sequence: 7 givenname: Sumaiya surname: Shabbir fullname: Shabbir, Sumaiya organization: Department of Periodontology, Dow University of Health Sciences, Karachi, Pakistan – sequence: 8 givenname: Farhan Raza surname: Khan fullname: Khan, Farhan Raza organization: Department of Surgery, Section Dentistry, Aga Khan University & Hospital, Karachi, Pakistan – sequence: 9 givenname: Ali surname: Sadiq fullname: Sadiq, Ali organization: Department of Surgery, Section Dentistry, Aga Khan University & Hospital, Karachi, Pakistan |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/37327229$$D View this record in MEDLINE/PubMed |
BookMark | eNo9kN1OwzAMhSMEYmPsghdAeQAKSbr-XU4TjEqTuACuJzd1S0abVEk6BK_HixENhmXZR5b1-cgX5FQbjYRccXbLGRN3EoYgRBKfkKngaRwxVmQTMndux0KkLBGZOCeTOIuDEMWUfC_p0IHEykTSaG9N12FNLeja9OorSNkprSR01FsVqmkoaK8qZbySju7RutHRwZrjBEJqCvVu3IdF6g0NHt1o2wNkQKtMHQ4dgAi-x7AEvdEtdb15Dzj6ofwbffbQIi3L8oauLdRIV7RFjRa6g6t_jvLKXZKzBjqH878-I68P9y-rx2jztC5Xy00kRZ74CPIm4ZgV0IRPxKlkcZHzJq1iKbOmWsRJwxPBq0UFPE8qbFJMJc9lnqU1Yl6AmJHrX-4wVj3W28GqHuzn9vhN8QN6X3yr |
CitedBy_id | crossref_primary_10_7759_cureus_50200 crossref_primary_10_1111_odi_14781 |
ContentType | Journal Article |
Copyright | 2023 American Academy of Periodontology. |
Copyright_xml | – notice: 2023 American Academy of Periodontology. |
DBID | NPM |
DOI | 10.1002/cap.10253 |
DatabaseName | PubMed |
DatabaseTitle | PubMed |
DatabaseTitleList | PubMed |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database |
DeliveryMethod | no_fulltext_linktorsrc |
Discipline | Dentistry |
EISSN | 2163-0097 |
ExternalDocumentID | 37327229 |
Genre | Journal Article |
GroupedDBID | 0R~ 1OC 33P 34H AAEUS AAHHS AANLZ AAXRX AAZKR ABCUV ABDQB ABJNI ABLJU ABQWH ABXGK ACAHQ ACCFJ ACCZN ACGFS ACGOF ACMXC ACPOU ACXBN ACXQS ADBBV ADBTR ADEOM ADKYN ADMGS ADOZA ADXAS ADZMN ADZOD AEEZP AEIGN AEQDE AEUYR AFFPM AFGKR AFPWT AHBTC AIACR AITYG AIURR AIWBW AJBDE ALMA_UNASSIGNED_HOLDINGS ALUQN AMYDB BFHJK C45 DCZOG DRFUL DRMAN DRSTM EBS FUBAC HGLYW I4R KBYEO LATKE LEEKS LUTES LYRES MEWTI MSFUL MSMAN MSSTM MXFUL MXMAN MXSTM NPM O9- OVD P2W PER ROL SUPJJ TEORI UMD WOHZO WXSBR ZZTAW |
ID | FETCH-LOGICAL-c285t-a8f51e79af00636c03981f6b3cc7fb435f1521b4ba185bef6e6c18c876dee89a2 |
IngestDate | Sat Sep 28 08:14:16 EDT 2024 |
IsPeerReviewed | true |
IsScholarly | true |
Keywords | smoker antibiotics chronic periodontitis probiotics |
Language | English |
License | 2023 American Academy of Periodontology. |
LinkModel | OpenURL |
MergedId | FETCHMERGED-LOGICAL-c285t-a8f51e79af00636c03981f6b3cc7fb435f1521b4ba185bef6e6c18c876dee89a2 |
PMID | 37327229 |
ParticipantIDs | pubmed_primary_37327229 |
PublicationCentury | 2000 |
PublicationDate | 2023-09-01 |
PublicationDateYYYYMMDD | 2023-09-01 |
PublicationDate_xml | – month: 09 year: 2023 text: 2023-09-01 day: 01 |
PublicationDecade | 2020 |
PublicationPlace | United States |
PublicationPlace_xml | – name: United States |
PublicationTitle | Clinical advances in periodontics |
PublicationTitleAlternate | Clin Adv Periodontics |
PublicationYear | 2023 |
SSID | ssj0000605272 |
Score | 2.2992365 |
Snippet | Probiotics are viable microorganisms, which if delivered in appropriate dose can provide health benefits. Lactobacillus reuteri (DM17938+ATCC PTA 5289) has... |
SourceID | pubmed |
SourceType | Index Database |
Title | A placebo-controlled randomized clinical trial of antibiotics versus probiotics as an adjuvant to nonsurgical periodontal treatment among smokers with Stage III, Grade C generalized periodontitis |
URI | https://www.ncbi.nlm.nih.gov/pubmed/37327229 |
hasFullText | |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwELa2IEEvFW8oD82BWwjk_TiuFkoXqb3Qit4q27GbBXazZbNCyt_j2D_VGTvJhhYQIK2iyE4iZ-eT_XnyzQxjL1WSSpFq4eZhzN0oKYQrijh0VaSLBOm9xxXFOx8cJvvH0YeT-GQ0uhiolta1eC2bX8aV_I9VsQ3tSlGy_2DZ_qHYgOdoXzyihfH4VzYeO0ZSJSq3VZx_RfqIi09RzWcNnvZhj7Y2B33yX1CMSGVyM5MgY70ihVbXwilhs8OLz2vk1zXR0gVFaH6zsyPlRMZNrAmfHOjTTbWi1bz6QqHAxq2LBPZMOdPp1AbB8EI5EyrVTO4vM67-SZRQaUiPJ92AW2lCK3Lvrt4I89-XvDGlCpwDVX6frXqn9ricW_ftx5KXgjc9PjluEc7XRrvwiZ_jm5or-_WmxKGZ-_ZmTcOHvpAg7MVeuJSZOTPw6bO0ZyW_11YHm21W8iUlrLA5igcoWc4NTMI0DNLAumH-3HslUXfXtcW20owm28PWcWRJgRdjb5fbygve9MPYZre6W6_sbQzHObrDdtrNCYwt0u6ykVrcY7ffkqCMagLeZz_GcB1xsEEcdIgDgzioNAwQBxZxsEEccPwtoEMc1BUMEAcDxEGPODCIgxZxQIgDgzhAxL0CgzeYwABv8BPeHrDjvXdHk323LQPiyiCLa5dnOvZVmnNNfDqRXphnvk5EKCVOMkj3NXFQEQmO3FMonahE-pnEZb5QKst58JDdwLGrxwx0niJ_l3Ee6CAqVJRLNErmS6qBECV58YQ9sv__6dLmejntLLP7256nbHsDxWfspsbJRT1HplqLFwYDlzjkog8 |
link.rule.ids | 786 |
linkProvider | National Library of Medicine |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=A+placebo-controlled+randomized+clinical+trial+of+antibiotics+versus+probiotics+as+an+adjuvant+to+nonsurgical+periodontal+treatment+among+smokers+with+Stage+III%2C+Grade+C+generalized+periodontitis&rft.jtitle=Clinical+advances+in+periodontics&rft.au=Ghazal%2C+Mehwish&rft.au=Ahmed%2C+Shahbaz&rft.au=Farooqui%2C+Waqas+Ahmed&rft.au=Khalid%2C+Fizza&rft.date=2023-09-01&rft.eissn=2163-0097&rft_id=info:doi/10.1002%2Fcap.10253&rft_id=info%3Apmid%2F37327229&rft_id=info%3Apmid%2F37327229&rft.externalDocID=37327229 |