Plasma carnitine levels in children with idiopathic epilepsy treated with old and new antiepileptic drugs

• Published in: Journal of pediatric neurology Vol. 10; no. 4; pp. 275 - 281
• Main Authors: Abd El-Aziz, Sahar A., El-Serogy, Hesham
• Format: Journal Article
• Language: English
• Published: New York Georg Thieme Verlag KG 01.12.2012; Stuttgart Thieme Medical Publishers Inc
• Subjects: Age; Antiepileptic agents; Carbamazepine; Carnitine; Children; Epilepsy; Family medical history; Fatty acids; lamotrigine; Metabolic disorders; Metabolism; Mitochondria; Neurology; oxcarbazepine; Pediatrics; Plasma; Studies; Valproic acid; epilepsy; antiepileptic drug; children; Carnitine

Abstract Prolonged antiepileptic drugs (AEDs) treatment can result in secondary carnitine deficiency. Clinical studies indicate a decrease in free and total carnitine levels in children treated with old-generation AEDs (especially valproate). A number of studies on the effect of valproic acid and/or...