Arginine-rich peptides and their internalization mechanisms

• Published in: Biochemical Society transactions Vol. 35; no. Pt 4; p. 784
• Main Authors: Futaki, S, Nakase, I, Tadokoro, A, Takeuchi, T, Jones, A T
• Format: Journal Article
• Language: English
• Published: England 01.08.2007
• Subjects: Animals; Arginine - genetics; Arginine - metabolism; Humans; Peptides - genetics; Peptides - metabolism; Protein Sorting Signals - physiology; Protein Transport - physiology

As the versatility and use of CPPs (cell-penetrating peptides) as intracellular delivery vectors have been widely accepted, the cellular uptake mechanisms that enable their efficient internalization have become the subject of much interest. Arginine-rich peptides, including HIV-1 Tatp (transactivato...