Delivered dose and vascular response after beta-radiation for in-stent restenosis: retrospective dosimetry and volumetric intravascular ultrasound analysis

• Published in: Circulation (New York, N.Y.) Vol. 106; no. 18; pp. 2334 - 2339
• Main Authors: Morino, Yoshihiro, Kaneda, Hideaki, Fox, Tim, Takagi, Atsushi, Hassan, Ali H M, Bonan, Raoul, Crocker, Ian, Lansky, Alexandra J, Laskey, Warren K, Suntharalingam, Mohan, Bonneau, Heidi N, Yock, Paul G, Honda, Yasuhiro, Fitzgerald, Peter J
• Format: Journal Article
• Language: English
• Published: United States American Heart Association, Inc 29.10.2002
• Subjects: Beta Particles - therapeutic use; Blood Vessel Prosthesis Implantation - adverse effects; Brachytherapy - methods; Brachytherapy - standards; Cohort Studies; Coronary Angiography; Coronary Artery Disease - diagnostic imaging; Coronary Artery Disease - therapy; Coronary Restenosis - radiotherapy; Coronary Vessels - diagnostic imaging; Coronary Vessels - drug effects; Coronary Vessels - surgery; Dose-Response Relationship, Radiation; Female; Humans; Linear Models; Male; Middle Aged; Radiation Dosage; Radiometry; Retrospective Studies; Stents - adverse effects; Treatment Outcome; Ultrasonography, Interventional; Vascular Patency

Observations from previous intracoronary radiation therapy trials noted a considerable discrepancy between the prescribed radiation dose and the dose actually delivered. The aims of this study were to investigate the effect of actual delivered dose on vascular changes and to test the appropriateness...