Malignant thymoma with metastases to the gastrointestinal tract and ovary: a case report and literature review

• Published in: American journal of clinical oncology Vol. 23; no. 2; p. 140
• Main Authors: Bott-Kothari, T, Aron, B S, Bejarano, P
• Format: Journal Article
• Language: English
• Published: United States 01.04.2000
• Subjects: Adult; Female; Gastrointestinal Neoplasms - secondary; Humans; Ovarian Neoplasms - secondary; Prognosis; Thymoma - secondary; Thymus Neoplasms - pathology; Time Factors
• ISSN: 0277-3732
• DOI: 10.1097/00000421-200004000-00007

This is the first clinical case report of a thoracic invasive thymoma metastatic to the ovary with disease noted in the entire abdomen including the pelvis 5 1/2 years after initial diagnosis. The involved areas of metastases include the distal ileum, peritoneal and serosal surfaces (including the surface of the distal colon, bladder, and pelvis), and the surface of the right ovary. The patient survived 13 years after her initial diagnosis and 7 1/2 years after discovery of her metastases. Thymomas are rare tumors but comprise the most common primary tumor of the anterior mediastinum. Extrathoracic metastases of malignant thymomas are also rare, and the literature reports that the most common sites for metastases are the liver, lung, lymph nodes, and bone. Extrathoracic disease is associated with a poor prognosis. The average time of survival after the diagnosis of metastases is 1.5 years.