Transcriptional regulation of Fe S biogenesis genes: A possible shield against arsenate toxicity activated by Yap1

• Published in: Biochimica et biophysica acta. General subjects Vol. 1862; no. 10; pp. 2152 - 2161
• Main Authors: da Silva, Sofia M., Batista-Nascimento, Liliana, Gaspar-Cordeiro, Ana, Vernis, Laurence, Pimentel, Catarina, Rodrigues-Pousada, Claudina
• Format: Journal Article
• Language: English
• Published: Elsevier 01.10.2018
• Subjects: Arsenates; Gene Expression Regulation, Fungal; Iron-Sulfur Proteins; Life Sciences; Oxidative Stress; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Transcription Factors; Transcriptional Activation; Iron homeostasis; Yap1; FeS biogenesis; Arsenate; Stress

In the eukaryotic model yeast Saccharomyces cerevisiae, arsenic (As) detoxification is regulated by two transcriptional factors, Yap8 and Yap1. Yap8 specifically controls As extrusion from the cell, whether Yap1 avoids arsenic-induced oxidative damages. Accordingly, cells lacking both Yap1 and Yap8...