CoQ10 deficiencies and MNGIE: Two treatable mitochondrial disorders

Although causative mutations have been identified for numerous mitochondrial disorders, few disease-modifying treatments are available. Two examples of treatable mitochondrial disorders are coenzyme Q10 (CoQ10 or ubiquinone) deficiency and mitochondrial neurogastrointestinal encephalomyopathy (MNGIE...

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Bibliographic Details
Published inBiochimica et biophysica acta Vol. 1820; no. 5; pp. 625 - 631
Main Authors Hirano, Michio, Garone, Caterina, Quinzii, Catarina M.
Format Journal Article
LanguageEnglish
Published Elsevier B.V 01.05.2012
Subjects
biosynthesis
cell transplantation
Coenzyme Q
genes
genetic disorders
in vivo studies
metabolites
Mitochondria
Mitochondrial DNA
MNGIE
mutation
patients
phosphorylase
stem cells
thymidine
Thymidine phosphorylase
toxicity
Ubiquinone
ubiquinones
Coenzyme Q
Mitochondria
Mitochondrial DNA
MNGIE
Ubiquinone
Thymidine phosphorylase
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ISSN0304-4165
0006-3002
1872-8006
0006-3002
DOI10.1016/j.bbagen.2012.01.006

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