Drug Release from ß-Cyclodextrin Complexes and Drug Transfer into Model Membranes Studied by Affinity Capillary Electrophoresis

• Published in: Pharmaceutical research Vol. 33; no. 5; pp. 1175 - 1181
• Main Authors: Darwish, Kinda A., Mrestani, Yahya, Rüttinger, Hans-Hermann, Neubert, Reinhard H. H.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.05.2016; Springer; Springer Nature B.V
• Subjects: Analysis; Anti-Inflammatory Agents, Non-Steroidal - administration & dosage; Anti-Inflammatory Agents, Non-Steroidal - chemistry; Antihypertensive Agents - administration & dosage; Antihypertensive Agents - chemistry; beta-Cyclodextrins - chemistry; Biochemistry; Biomedical and Life Sciences; Biomedical Engineering and Bioengineering; Biomedicine; Capillary electrophoresis; Cholesterol; Cholesterol - chemistry; Cyclodextrins; Drug Carriers - chemistry; Drug delivery systems; Drug Liberation; Electrophoresis; Electrophoresis, Capillary; Ibuprofen; Ibuprofen - administration & dosage; Ibuprofen - chemistry; Liposomes - chemistry; Medical Law; Pharmaceutical sciences; Pharmacology/Toxicology; Pharmacy; Phospholipids - chemistry; Propranolol - administration & dosage; Propranolol - chemistry; Research Paper; Surface active agents; affinity capillary electrophoresis; drug transfer; drug release; cyclodextrin complexes; liposome model membrane

Purpose Is to characterize the drug release from the ß-cyclodextrin (ß-CD) cavity and the drug transfer into model membranes by affinity capillary electrophoresis. Phospholipid liposomes with and without cholesterol were used to mimic the natural biological membrane. Methods The interaction of catio...