Antibody profiles induced by Trypanosoma cruzi in chagasic patients with previous or current exposure to mycobacteria

• Published in: Pathogens and disease Vol. 74; no. 9; p. ftw109
• Main Authors: Peverengo, Luz, Prochetto, Estefanía, Rodeles, Luz, Valenzuela, Ignacio, Marcipar, Iván Sergio, Bottasso, Oscar, Vicco, Miguel Hernán
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 01.12.2016
• Subjects: Antibodies; Antibodies, Protozoan - blood; Antibodies, Protozoan - immunology; Bacillus Calmette-Guerin vaccine; BCG; Chagas disease; Chagas Disease - immunology; Chagas Disease - microbiology; Chagas Disease - parasitology; Coinfection; Host-Parasite Interactions - immunology; Host-Pathogen Interactions - immunology; Humans; Immune response; Immune system; Immunology; Microorganisms; Mycobacterium - immunology; Mycobacterium Infections - immunology; Mycobacterium Infections - microbiology; Parasitic diseases; Parasitic protozoa; Patients; Protozoa; Trypanosoma cruzi; Trypanosoma cruzi - immunology; Tuberculosis; Vaccination; Vector-borne diseases; Chagas disease; BCG vaccination; tuberculosis
• ISSN: 2049-632X; 2049-632X
• DOI: 10.1093/femspd/ftw109

Since the immune response mounted by the host to a particular microorganism might be influenced by the acquired immunological experience due to previous contact with other microorganisms, we performed a cross-sectional study to explore the pattern of Trypanosoma cruzi infection-related antibodies in T. cruzi-seropositive individuals presenting concomitant tuberculosis, or the antecedent of BCG vaccination. Sampled individuals were grouped as follows: patients with Chagas disease, not vaccinated with BCG, who further developed pulmonary tuberculosis; individuals with Chagas disease, BCG-vaccinated; and subjects with Chagas disease, presenting neither BCG scar nor tuberculosis disease. Non-vaccinated individuals or without tuberculosis, presented the highest values of anti-PH (P < 0.001), anti-FRA (P < 0.001), anti-p2β (P = 0.0023) and anti-B13 (P < 0.001) antibodies. The present findings constitute the first demonstration of the potential influence of concomitant tuberculosis on Chagas disease.