Update on exploring the tumors of multiple endocrine neoplasia type 1 in mouse models for basic and preclinical studies

• Published in: International journal of endocrine oncology Vol. 4; no. 3; pp. 113 - 116
• Main Author: Agarwal, Sunita K
• Format: Journal Article
• Language: English
• Published: London Future Medicine Ltd 01.08.2017
• Subjects: endocrine tumor; Endocrinology; epigenetic; Epigenetics; Genes; MEN1; menin; Mutation; Neuroendocrine tumors; Pancreas; PanNET; PNET; Rodents; tissue-specific; Tumorigenesis

Compound-mutant mice with germline homozygous deletion of the gene that encodes for the apoptosis repressor with CARD (ARC; Nol3-/- ) and Men1 deletion in the whole pancreas (Men1f/f ; Pdx1-Cre) did not alter PNET (insulinoma) burden (9). [...]ARC upregulation may not be a critical second hit in ins...