Pharmacokinetic and pharmacodynamic principles

• Published in: Baillière's clinical anaesthesiology Vol. 5; no. 3; pp. 489 - 511
• Main Authors: Henthorn, Thomas K., Avram, Michael J.
• Format: Journal Article
• Language: English
• Published: London Elsevier Ltd 01.12.1991; Baillière Tindall
• Subjects: Anesthetics. Neuromuscular blocking agents; Biological and medical sciences; Medical sciences; Neuropharmacology; Pharmacology. Drug treatments; Human; Drug; Anesthesia; Pharmacogenetics; Activity concentration relation; Pharmacokinetics

New drugs continue to be introduced into anaesthetic practice. Often innovation involves a modification of pharmacokinetic properties rather than pharmacologic activity. Besides selecting drugs based on its pharmacokinetic profile, the anaesthetist is increasingly faced with giving repetitive doses...