N6-methyladenosine (m6A) dysregulation contributes to network excitability in temporal lobe epilepsy

• Published in: JCI insight Vol. 10; no. 14
• Main Authors: Mathoux, Justine, Wilson, Marc-Michel, Srinivas, Sujithra, Litovskich, Gabrielle, Villalba Benito, Leticia, Tran, Cindy, Kesavan, Jaideep, Harnett, Aileen, Auer, Theresa, Sanz-Rodriguez, Amaya, Kh. A.E. Alkhayyat, Mohammad, Sullivan, Mairéad, Liu, Zining, Huang, Yifan, Lacey, Austin, Delanty, Norman, Cryan, Jane, Brett, Francesca M., Farrell, Michael A., O’Brien, Donncha F., Casillas-Espinosa, Pablo M., Jimenez-Mateos, Eva M., Glennon, Jeffrey C., Canavan, Mary, Henshall, David C., Brennan, Gary P.
• Format: Journal Article
• Language: English
• Published: United States American Society for Clinical Investigation 22.07.2025
• Subjects: Adenosine - analogs & derivatives; Adenosine - genetics; Adenosine - metabolism; Animals; Disease Models, Animal; Epilepsy, Temporal Lobe - genetics; Epilepsy, Temporal Lobe - metabolism; Epilepsy, Temporal Lobe - physiopathology; Female; Gene Expression Regulation; Hippocampus - metabolism; Humans; Male; Mice; Mice, Inbred C57BL; Proteomics; Transcriptome; Cell biology; Epigenetics; Neuroscience; Mouse models; Epilepsy

Analogous to DNA methylation and protein phosphorylation, it is now well understood that RNA is also subject to extensive processing and modification. N6-methyladenosine (m6A) is the most abundant internal RNA modification and regulates RNA fate in several ways, including stability and translational...