Celastrol suppresses humoral immune responses and autoimmunity by targeting the COMMD3/8 complex

Celastrol, a bioactive molecule extracted from the plant, has been shown to exhibit anti-inflammatory properties. However, its mechanism of action has not been fully elucidated. Here, we show that celastrol suppresses humoral immune responses and autoimmunity by disabling a protein complex consistin...

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Bibliographic Details
Published inScience immunology Vol. 8; no. 81; p. eadc9324
Main Authors Shirai, Taiichiro, Nakai, Akiko, Ando, Emiko, Fujimoto, Jun, Leach, Sarah, Arimori, Takao, Higo, Daisuke, van Eerden, Floris J, Tulyeu, Janyerkye, Liu, Yu-Chen, Okuzaki, Daisuke, Murayama, Masanori A, Miyata, Haruhiko, Nunomura, Kazuto, Lin, Bangzhong, Tani, Akiyoshi, Kumanogoh, Atsushi, Ikawa, Masahito, Wing, James B, Standley, Daron M, Takagi, Junichi, Suzuki, Kazuhiro
Format Journal Article
LanguageEnglish
Published United States 31.03.2023
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