A thermo-/pH-responsive hydrogel (PNIPAM-PDMA-PAA) with diverse nanostructures and gel behaviors as a general drug carrier for drug release

• Published in: Polymer chemistry Vol. 9; no. 29; pp. 4063 - 4072
• Main Authors: Chen, Yan, Gao, Yuting, da Silva, Lucília P., Pirraco, Rogério P., Ma, Mengdi, Yang, Liming, Reis, Rui L., Chen, Jie
• Format: Journal Article
• Language: English
• Published: Cambridge Royal Society of Chemistry 07.08.2018
• Subjects: Addition polymerization; Block copolymers; Chemical synthesis; Computer simulation; Copolymers; Core-shell structure; Drug carriers; Drug delivery systems; Electronegativity; Human behavior; Hydrogels; Methylene blue; Molecular chains; Nanostructure; Polymer chemistry; Sol-gel processes; Sustained release; Toxicity

The aim of this research was to develop thermo- and pH-responsive hydrogels based on H-bonds for the sustained release of the small-molecule model drug Methylene Blue (MB). The thermo- or pH-sensitive triblock copolymer based on PNIPAM or PAA was synthesized by sequential RAFT polymerization and hyd...