Nogo-a expression in glial CNS tumors: a tool to differentiate between oligodendrogliomas and other gliomas?

• Published in: The American journal of surgical pathology Vol. 32; no. 10; p. 1444
• Main Authors: Kuhlmann, Tanja, Gutenberg, Angelika, Schulten, Hans-Jürgen, Paulus, Werner, Rohde, Veit, Bruck, Wolfgang
• Format: Journal Article
• Language: English
• Published: United States 01.10.2008
• Subjects: Astrocytoma - chemistry; Biomarkers, Tumor - analysis; Brain Neoplasms - chemistry; Brain Neoplasms - genetics; Brain Neoplasms - pathology; Diagnosis, Differential; Ependymoma - chemistry; Gene Expression Regulation, Neoplastic; Glioblastoma - chemistry; Glioma - chemistry; Glioma - genetics; Glioma - pathology; Humans; Immunohistochemistry; Meningioma - chemistry; Meningioma - genetics; Meningioma - pathology; Myelin Proteins - analysis; Neoplasm Staging; Neurocytoma - chemistry; Neurocytoma - genetics; Neurocytoma - pathology; Nogo Proteins; Oligodendroglioma - chemistry; Oligodendroglioma - genetics; Oligodendroglioma - pathology

Gliomas are the most frequent primary brain tumors. In a minority of cases, the differentiation between astrocytomas and oligodendrogliomas based on morphologic characteristics alone can be difficult; though it is important, as patients with oligodendrogliomas follow a more favorable clinical course...