Nogo-a expression in glial CNS tumors: a tool to differentiate between oligodendrogliomas and other gliomas?

• Published in: The American journal of surgical pathology Vol. 32; no. 10; p. 1444
• Main Authors: Kuhlmann, Tanja, Gutenberg, Angelika, Schulten, Hans-Jürgen, Paulus, Werner, Rohde, Veit, Bruck, Wolfgang
• Format: Journal Article
• Language: English
• Published: United States 01.10.2008
• Subjects: Astrocytoma - chemistry; Biomarkers, Tumor - analysis; Brain Neoplasms - chemistry; Brain Neoplasms - genetics; Brain Neoplasms - pathology; Diagnosis, Differential; Ependymoma - chemistry; Gene Expression Regulation, Neoplastic; Glioblastoma - chemistry; Glioma - chemistry; Glioma - genetics; Glioma - pathology; Humans; Immunohistochemistry; Meningioma - chemistry; Meningioma - genetics; Meningioma - pathology; Myelin Proteins - analysis; Neoplasm Staging; Neurocytoma - chemistry; Neurocytoma - genetics; Neurocytoma - pathology; Nogo Proteins; Oligodendroglioma - chemistry; Oligodendroglioma - genetics; Oligodendroglioma - pathology
• DOI: 10.1097/PAS.0b013e31817ce978

Gliomas are the most frequent primary brain tumors. In a minority of cases, the differentiation between astrocytomas and oligodendrogliomas based on morphologic characteristics alone can be difficult; though it is important, as patients with oligodendrogliomas follow a more favorable clinical course. Here we report on the immunohistochemical expression pattern of the oligodendrocytic marker Nogo-A in 113 central nervous system tumors including 28 oligodendrogliomas [15, World Health Organization (WHO) grade II; 13, grade WHO III], 50 astrocytomas [10, grade WHO II; 11, grade WHO III; 29 glioblastoma multiforme (GBM)], 11 ependymomas WHO grade II, 7 central neurocytomas, 2 dysembryoplastic neuroepithelial tumors (DNTs), 5 clear cell meningiomas, and 10 metastases to the brain. The oligodendrocytic marker Nogo-A was found to be strongly expressed in 71% of oligodendrogliomas, but in 0% of ependymomas WHO grade II, astrocytomas WHO grade II or III, DNTs, central neurocytomas, or clear cell meningiomas. In GBM, a subgroup of tumors (24%) showed strong expression of Nogo-A coincidently with Ki67 positivity but glial fibrillary acidic protein-negativity. However, neither in oligodendrogliomas nor GBM was a correlation between the loss of 1p19q and the extent of Nogo-A expression observed. Our findings indicate that Nogo-A is strongly expressed in the majority of oligodendrogliomas and might be a helpful marker to distinguish oligodendrogliomas from astrocytomas WHO grades II and III as well as ependymomas. They also support the hypothesis that GBM may be a heterogeneous group of tumors derived from different progenitor cells.