Effect of estrogen receptor α on cardiopulmonary adaptation to chronic developmental hypoxia in a rat model

• Published in: American journal of physiology. Lung cellular and molecular physiology Vol. 326; no. 6; pp. L786 - L795
• Main Authors: Severyn, Nicholas T., Esparza, Patricia, Gao, Huanling, Mickler, Elizabeth A., Albrecht, Marjorie E., Fisher, Amanda J., Yakubov, Bahktiyor, Cook, Todd G., Slaven, James E., Walts, Avram D., Tepper, Robert S., Lahm, Tim
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 01.06.2024
• Subjects: Adaptation, Physiological; Altitude; Animals; Disease Models, Animal; Estrogen Receptor alpha - genetics; Estrogen Receptor alpha - metabolism; Female; Hypoxia - metabolism; Hypoxia - physiopathology; Lung - metabolism; Lung - pathology; Male; Rats; Rats, Sprague-Dawley; Vascular Endothelial Growth Factor A - genetics; Vascular Endothelial Growth Factor A - metabolism; adaptation to hypoxia; pulmonary hypertension; estrogen receptor α; lung development
• ISSN: 1040-0605; 1522-1504; 1522-1504
• DOI: 10.1152/ajplung.00161.2023

By exposing novel loss-of-function estrogen receptor alpha (Erα) mutant rats to a novel model of human high-altitude exposure, we demonstrate that ERα has subtle but inconsistent effects on endpoints relevant to cardiopulmonary adaptation to chronic hypoxia. Given that we observed some histologic, s...