A transcriptomic biomarker predictive of cell proliferation for use in adverse outcome pathway-informed testing and assessment

• Published in: Toxicological sciences Vol. 201; no. 2; pp. 174 - 189
• Main Authors: Corton, J Christopher, Ledbetter, Victoria, Cohen, Samuel M, Atlas, Ella, Yauk, Carole L, Liu, Jie
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 01.10.2024
• Subjects: Adverse Outcome Pathways; Animals; Biomarkers - metabolism; Cell Proliferation - drug effects; Female; Gene Expression Profiling; Humans; Male; MCF-7 Cells; Mice; Rats; Transcriptome - drug effects; gene expression biomarkers; hepatocarcinogens; cell proliferation; DNA damage; estrogen receptor α; gene expression compendium

High-throughput transcriptomics (HTTr) is increasingly being used to identify molecular targets of chemicals that can be linked to adverse outcomes. Cell proliferation (CP) is an important key event in chemical carcinogenesis. Here, we describe the construction and characterization of a gene express...