Alveolar macrophage-derived chemotactic factor: kinetics of in vitro production and partial characterization

• Published in: The Journal of clinical investigation Vol. 65; no. 2; pp. 268 - 276
• Main Authors: Merrill, W W, Naegel, G P, Matthay, R A, Reynolds, H Y
• Format: Journal Article
• Language: English
• Published: United States 01.02.1980
• Subjects: Cells, Cultured; Chemotactic Factors - biosynthesis; Chemotactic Factors - pharmacology; Female; Granulocytes - drug effects; Humans; Immunoglobulin G - administration & dosage; In Vitro Techniques; Kinetics; Leukocytes - drug effects; Macrophages - metabolism; Male; Molecular Weight; Pulmonary Alveoli - metabolism; Smoking - physiopathology; Zymosan - pharmacology

Alveolar macrophages are the initial phagocytic cells that encounter foreign material and particulates deposited in the terminal airways. We have examined a mechanism by which these cells, after phagocytic challenge, may control or amplify the inflammatory response in lung parenchyma. Normal human a...