Hb Warsaw (beta 42 Phe----Val): an unstable hemoglobin with decreased oxygen affinity. I. Hematologic and clinical expression

• Published in: American journal of hematology Vol. 32; no. 1; p. 36
• Main Authors: Honig, G R, Telfer, M C, Rosenblum, B B, Vida, L N
• Format: Journal Article
• Language: English
• Published: United States 01.09.1989
• Subjects: Adult; Amino Acid Sequence; Anemia, Hemolytic - blood; Anemia, Hemolytic - genetics; Chronic Disease; Cyanosis - blood; Cyanosis - genetics; Drug Stability; Hemoglobins - analysis; Hemoglobins, Abnormal - metabolism; Humans; Male; Oxygen - blood; Pedigree

Four members in two generations of a Polish-American family exhibited findings of congenital Heinz-body hemolytic anemia accompanied by cyanosis. Two of the affected family members have also developed severe pulmonary hypertension, with a fatal outcome in one of them. Blood from the affected individ...