Association of Circulating Cell-Free Mitochondrial DNA With Sudden Sensorineural Hearing Loss

• Published in: Otolaryngology-head and neck surgery Vol. 173; no. 1; p. 193
• Main Authors: Yang, Chao-Hui, Yang, Ming-Yu, Lin, Wei-Che, Hwang, Chung-Feng, Lin, Yu-Tsai, Wu, Ching-Nung, Chen, I-Ya, Tsai, Ming-Hsien
• Format: Journal Article
• Language: English
• Published: England 01.07.2025
• Subjects: Adult; Aged; Case-Control Studies; Cell-Free Nucleic Acids - blood; DNA, Mitochondrial - blood; Female; Hearing Loss, Sensorineural - blood; Hearing Loss, Sensorineural - drug therapy; Hearing Loss, Sensorineural - genetics; Hearing Loss, Sudden - blood; Hearing Loss, Sudden - drug therapy; Hearing Loss, Sudden - genetics; Humans; Male; Middle Aged; Prospective Studies; treatment outcomes; circulating cell‐free mitochondrial DNA; sudden sensorineural hearing loss

To evaluate the association of circulating cell-free mitochondrial DNA (ccf-mtDNA) levels with the severity and treatment outcomes of sudden sensorineural hearing loss (SSNHL). Observational prospective study. Tertiary academic medical center. Plasma samples were collected from patients diagnosed wi...