Further insights into the pathophysiology of hyperapobetalipoproteinemia: role of basic proteins I, II, III

• Published in: Clinical chemistry (Baltimore, Md.) Vol. 37; no. 3; pp. 317 - 326
• Main Authors: Kwiterovich, PO, Jr, Motevalli, M, Miller, M, Bachorik, PS, Kafonek, SD, Chatterjee, S, Beaty, T, Virgil, D
• Format: Journal Article
• Language: English
• Published: England Am Assoc Clin Chem 01.03.1991
• Subjects: Animals; Apolipoproteins - blood; Apolipoproteins - physiology; Apolipoproteins B - blood; Apolipoproteins B - genetics; Blood Proteins - physiology; Complement C3a - analogs & derivatives; Fibroblasts - metabolism; Humans; Hyperlipoproteinemias - genetics; Hyperlipoproteinemias - metabolism; Hyperlipoproteinemias - physiopathology; Lipoproteins - blood; Lipoproteins - genetics; Lipoproteins - physiology

Hyperapobetalipoproteinemia (hyperapoB), a familial lipoprotein disorder characterized by an increase in small, dense, low-density lipoprotein (LDL) particles, is strongly associated with coronary artery disease. There are two metabolic defects in hyperapoB: an increased synthesis of a very-low-dens...