Retinoic acid in patients with radioiodine non-responsive thyroid carcinoma

• Published in: Journal of endocrinological investigation Vol. 27; no. 4; pp. 334 - 339
• Main Authors: Coelho, S Mendes, Corbo, R, Buescu, A, Carvalho, D P, Vaisman, M
• Format: Journal Article
• Language: English
• Published: Italy 01.04.2004
• Subjects: Adenocarcinoma, Follicular - pathology; Adenocarcinoma, Follicular - therapy; Adult; Aged; Carcinoma - pathology; Carcinoma - therapy; Carcinoma, Papillary - pathology; Carcinoma, Papillary - therapy; Female; Humans; Iodine Radioisotopes - therapeutic use; Isotretinoin - adverse effects; Isotretinoin - therapeutic use; Male; Middle Aged; Prospective Studies; Radionuclide Imaging; Thyroglobulin - blood; Thyroid Neoplasms - diagnostic imaging; Thyroid Neoplasms - pathology; Thyroid Neoplasms - therapy; Treatment Outcome

De-differentiated thyroid carcinoma is characterized by loss of thyroid-specific functions and properties. The therapeutic options for this type of thyroid cancer are limited and generally not efficient. Recent studies with retinoic acid (RA) have shown that this drug can induce re-differentiation o...