Aggregation and neurotoxicity of alpha-synuclein and related peptides

• Published in: Biochemical Society transactions Vol. 30; no. 4; p. 559
• Main Authors: el-Agnaf, O M A, Irvine, G B
• Format: Journal Article
• Language: English
• Published: England 01.08.2002
• Subjects: alpha-Synuclein; Alzheimer Disease - pathology; Animals; Brain - pathology; Cell Survival - drug effects; Humans; Molecular Weight; Nerve Tissue Proteins - chemistry; Nerve Tissue Proteins - toxicity; Neurotoxins - chemistry; Neurotoxins - toxicity; PC12 Cells; Phosphoproteins - chemistry; Phosphoproteins - toxicity; Protein Conformation; Protein Structure, Secondary; Rats; Synucleins

Fibrillar deposits of alpha-synuclein occur in several neurodegenerative diseases. Two mutant forms of alpha-synuclein have been associated with early-onset Parkinson's disease, and a fragment has been identified as the non-amyloid-beta peptide component of Alzheimer's disease amyloid (NAC...