A requirement for ERK-dependent Dicer phosphorylation in coordinating oocyte-to-embryo transition in C. elegans

• Published in: Developmental cell Vol. 31; no. 5; pp. 614 - 628
• Main Authors: Drake, Melanie, Furuta, Tokiko, Suen, Kin Man, Gonzalez, Gabriel, Liu, Bin, Kalia, Awdhesh, Ladbury, John E, Fire, Andrew Z, Skeath, James B, Arur, Swathi
• Format: Journal Article
• Language: English
• Published: United States 08.12.2014
• Subjects: Animals; Base Sequence - physiology; Caenorhabditis elegans - embryology; Caenorhabditis elegans - enzymology; MAP Kinase Signaling System - physiology; Mice; Oocytes - metabolism; Oogenesis - physiology; Phosphorylation; Ribonuclease III - metabolism; RNA, Double-Stranded - metabolism

Signaling pathways and small RNAs direct diverse cellular events, but few examples are known of defined signaling pathways directly regulating small RNA biogenesis. We show that ERK phosphorylates Dicer on two conserved residues in its RNase IIIb and double-stranded RNA (dsRNA)-binding domains and t...