Novel nanocomposite scaffold based on gelatin/PLGA-PEG-PLGA hydrogels embedded with TGF-β1 for chondrogenic differentiation of human dental pulp stem cells in vitro
•Nanocomposite hydrogels consisted of gelatin and PLGA-PEG-PLGA copolymer were prepared and characterized.•For the whole time of the experiment, the gelatin/PLGA-PEG-PLGA composite hydrogel displayed biocompatibility with human dental pulp stem cells.•As regards cell viability, ECM production as wel...
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Published in | International journal of biological macromolecules Vol. 201; pp. 270 - 287 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
Netherlands
Elsevier B.V
15.03.2022
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Abstract | •Nanocomposite hydrogels consisted of gelatin and PLGA-PEG-PLGA copolymer were prepared and characterized.•For the whole time of the experiment, the gelatin/PLGA-PEG-PLGA composite hydrogel displayed biocompatibility with human dental pulp stem cells.•As regards cell viability, ECM production as well as differentiation of hDPSCs into chondrocyte-like cells, gelatin/PLGA-PEG-PLGA hydrogel demonstrated to be the promising carrier for hDPSCs.•The gelatin/PLGA-PEG-PLGA composite hydrogels exhibited the modulus comparative to articular cartilage and desirable biocompatibility to articular chondrocytes.
In the current study, a novel nanocomposite hydrogel scaffold comprising of natural-based gelatin and synthetic-based (poly D, L (lactide-co-glycolide) -b- poly (ethylene glycol)-b- poly D, L (lactide-co-glycolide) (PLGA-PEG-PLGA) triblock copolymer was developed and loaded with transforming growth factor- β1 (TGF-β1).
Synthesized scaffolds' chemical structure was examined by 1H NMR and ATR-FTIR. Scanning electron microscopy (SEM) confirmed particle size and morphology of the prepared nanoparticles as well as the scaffolds. The morphology analysis revealed a porous interconnected structure throughout the scaffold with a pore size dimension of about 202.05 µm. The swelling behavior, in vitro degradation, mechanical properties, density, and porosity were also evaluated. Phalloidin/DAPI staining was utilized for confirming the extended cytoskeleton of the chondrocytes. Alcian blue staining was conducted to determine cartilaginous matrix sulfated glycosaminoglycan (sGAG) synthesis. Eventually, over a period of 21 days, a real-time RT-PCR analysis was applied to measure the mRNA expression of chondrogenic marker genes, type-II collagen, SOX 9, and aggrecan, in hDPSCs cultured for up to 21 days to study the influence of gelatin/PLGA-PEG-PLGA-TGF-β1 hydrogels on hDPSCs. The findings of the cell-encapsulating hydrogels analysis suggested that the adhesion, viability, and chondrogenic differentiation of hDPSCs improved by gelatin/PLGA-PEG-PLGA-TGF-β1 nanocomposite hydrogels. These data supported the conclusion that gelatin/PLGA-PEG-PLGA-TGF-β1 nanocomposite hydrogels render the features that allow thein vitrofunctionality of encapsulated hDPSCs and hence can contribute the basis for new effective strategies for the treatment of cartilage injuries. |
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AbstractList | In the current study, a novel nanocomposite hydrogel scaffold comprising of natural-based gelatin and synthetic-based (poly D, L (lactide-co-glycolide) -b- poly (ethylene glycol)-b- poly D, L (lactide-co-glycolide) (PLGA-PEG-PLGA) triblock copolymer was developed and loaded with transforming growth factor- β1 (TGF-β1). Synthesized scaffolds' chemical structure was examined by
H NMR and ATR-FTIR. Scanning electron microscopy (SEM) confirmed particle size and morphology of the prepared nanoparticles as well as the scaffolds. The morphology analysis revealed a porous interconnected structure throughout the scaffold with a pore size dimension of about 202.05 µm. The swelling behavior, in vitro degradation, mechanical properties, density, and porosity were also evaluated. Phalloidin/DAPI staining was utilized for confirming the extended cytoskeleton of the chondrocytes. Alcian blue staining was conducted to determine cartilaginous matrix sulfated glycosaminoglycan (sGAG) synthesis. Eventually, over a period of 21 days, a real-time RT-PCR analysis was applied to measure the mRNA expression of chondrogenic marker genes, type-II collagen, SOX 9, and aggrecan, in hDPSCs cultured for up to 21 days to study the influence of gelatin/PLGA-PEG-PLGA-TGF-β1 hydrogels on hDPSCs. The findings of the cell-encapsulating hydrogels analysis suggested that the adhesion, viability, and chondrogenic differentiation of hDPSCs improved by gelatin/PLGA-PEG-PLGA-TGF-β1 nanocomposite hydrogels. These data supported the conclusion that gelatin/PLGA-PEG-PLGA-TGF-β1 nanocomposite hydrogels render the features that allow thein vitrofunctionality of encapsulated hDPSCs and hence can contribute the basis for new effective strategies for the treatment of cartilage injuries. •Nanocomposite hydrogels consisted of gelatin and PLGA-PEG-PLGA copolymer were prepared and characterized.•For the whole time of the experiment, the gelatin/PLGA-PEG-PLGA composite hydrogel displayed biocompatibility with human dental pulp stem cells.•As regards cell viability, ECM production as well as differentiation of hDPSCs into chondrocyte-like cells, gelatin/PLGA-PEG-PLGA hydrogel demonstrated to be the promising carrier for hDPSCs.•The gelatin/PLGA-PEG-PLGA composite hydrogels exhibited the modulus comparative to articular cartilage and desirable biocompatibility to articular chondrocytes. In the current study, a novel nanocomposite hydrogel scaffold comprising of natural-based gelatin and synthetic-based (poly D, L (lactide-co-glycolide) -b- poly (ethylene glycol)-b- poly D, L (lactide-co-glycolide) (PLGA-PEG-PLGA) triblock copolymer was developed and loaded with transforming growth factor- β1 (TGF-β1). Synthesized scaffolds' chemical structure was examined by 1H NMR and ATR-FTIR. Scanning electron microscopy (SEM) confirmed particle size and morphology of the prepared nanoparticles as well as the scaffolds. The morphology analysis revealed a porous interconnected structure throughout the scaffold with a pore size dimension of about 202.05 µm. The swelling behavior, in vitro degradation, mechanical properties, density, and porosity were also evaluated. Phalloidin/DAPI staining was utilized for confirming the extended cytoskeleton of the chondrocytes. Alcian blue staining was conducted to determine cartilaginous matrix sulfated glycosaminoglycan (sGAG) synthesis. Eventually, over a period of 21 days, a real-time RT-PCR analysis was applied to measure the mRNA expression of chondrogenic marker genes, type-II collagen, SOX 9, and aggrecan, in hDPSCs cultured for up to 21 days to study the influence of gelatin/PLGA-PEG-PLGA-TGF-β1 hydrogels on hDPSCs. The findings of the cell-encapsulating hydrogels analysis suggested that the adhesion, viability, and chondrogenic differentiation of hDPSCs improved by gelatin/PLGA-PEG-PLGA-TGF-β1 nanocomposite hydrogels. These data supported the conclusion that gelatin/PLGA-PEG-PLGA-TGF-β1 nanocomposite hydrogels render the features that allow thein vitrofunctionality of encapsulated hDPSCs and hence can contribute the basis for new effective strategies for the treatment of cartilage injuries. |
Author | Aghazadeh, Zahra Hanaee, Jalal Davaran, Soodabeh Khatibi, Ali Samiei, Mohammad Navali, Amir Mohammad Ghandforoushan, Parisa |
Author_xml | – sequence: 1 givenname: Parisa surname: Ghandforoushan fullname: Ghandforoushan, Parisa organization: Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran – sequence: 2 givenname: Jalal surname: Hanaee fullname: Hanaee, Jalal organization: Department of Medicinal Chemistry, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran – sequence: 3 givenname: Zahra surname: Aghazadeh fullname: Aghazadeh, Zahra organization: Stem Cell Research Center, Oral Medicine department, Tabriz University of Medical Sciences, Tabriz, Iran – sequence: 4 givenname: Mohammad surname: Samiei fullname: Samiei, Mohammad organization: Department of Endodontics, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran – sequence: 5 givenname: Amir Mohammad surname: Navali fullname: Navali, Amir Mohammad organization: Department of Orthopedy, Tabriz University of Medical Sciences, Tabriz, Iran – sequence: 6 givenname: Ali surname: Khatibi fullname: Khatibi, Ali organization: Department of biotechnology, Alzahra University, Tehran, Iran – sequence: 7 givenname: Soodabeh surname: Davaran fullname: Davaran, Soodabeh email: davaran@tbzmed.ac.ir organization: Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/34998887$$D View this record in MEDLINE/PubMed |
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Keywords | Cartilage tissue engineering PBS DMEM Chondrogenic differentiation h-DPSCs Dental pulp stem cells FBS Gelatin/PLGA-PEG-PLGA Nanocomposite scaffold MTT ELISA |
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Snippet | •Nanocomposite hydrogels consisted of gelatin and PLGA-PEG-PLGA copolymer were prepared and characterized.•For the whole time of the experiment, the... In the current study, a novel nanocomposite hydrogel scaffold comprising of natural-based gelatin and synthetic-based (poly D, L (lactide-co-glycolide) -b-... |
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SubjectTerms | Cartilage tissue engineering Cell Differentiation Chondrogenesis Chondrogenic differentiation Dental Pulp - metabolism Dental pulp stem cells Gelatin - chemistry Gelatin/PLGA-PEG-PLGA Humans Hydrogels - chemistry Hydrogels - pharmacology Nanocomposite scaffold Nanocomposites Polyesters Polyethylene Glycols Stem Cells Tissue Engineering - methods Transforming Growth Factor beta1 - metabolism |
Title | Novel nanocomposite scaffold based on gelatin/PLGA-PEG-PLGA hydrogels embedded with TGF-β1 for chondrogenic differentiation of human dental pulp stem cells in vitro |
URI | https://dx.doi.org/10.1016/j.ijbiomac.2021.12.097 https://www.ncbi.nlm.nih.gov/pubmed/34998887 https://search.proquest.com/docview/2618517013 |
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