CD8+ T-cell exhaustion in cancer: mechanisms and new area for cancer immunotherapy

• Published in: Briefings in functional genomics Vol. 18; no. 2; pp. 99 - 106
• Main Authors: He, Qi-Feng, Xu, Yong, Li, Jun, Huang, Zheng-Ming, Li, Xiu-Hui, Wang, Xiaochen
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 22.03.2019
• Subjects: apoptosis; cytokines; genomics; immunity; immunotherapy; cancer; T-cell exhaustion; CD8; T cell; immunotherapy

Abstract Immunotherapies have emerged as the most promising area in cancer treatments in recent years. CD8+ T cells, as one of the primary effector cells of anticancer immunity, however, when infiltrating in cancer tissues, are generally in dysfunctional states termed T-cell exhaustion. Exhausted CD...