Effects of trientine and penicillamine on intestinal copper uptake: A mechanistic 64Cu PET/CT study in healthy humans

• Published in: Hepatology (Baltimore, Md.) Vol. 79; no. 5; pp. 1065 - 1074
• Main Authors: Kirk, Frederik Teicher, Munk, Ditte Emilie, Swenson, Eugene Scott, Quicquaro, Adam Michael, Vendelbo, Mikkel Holm, Schilsky, Michael L., Ott, Peter, Sandahl, Thomas Damgaard
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 13.12.2023
• Subjects: Original : Liver Failure/Cirrhosis/Portal Hypertension

Background and Aims: Trientine (TRI) and D-penicillamine (PEN) are used to treat copper overload in Wilson disease. Their main mode of action is thought to be through the facilitation of urinary copper excretion. In a recent study, TRI was noninferior to PEN despite lower 24-hour urinary copper excr...