Brainstem-type Lewy body disease presenting with progressive autonomic failure and lethargy
The authors report an autopsy case characterized by progressive lethargy and autonomic failure with a distinctive pattern of occurrence of Lewy bodies. Autonomic dysfunction such as sleep apnea, orthostatic hypotension, dysuria, and hypohidrosis predominated with lethargy, whereas parkinsonism was n...
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Published in | Clinical autonomic research Vol. 10; no. 3; pp. 139 - 143 |
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Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
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Germany
01.06.2000
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Abstract | The authors report an autopsy case characterized by progressive lethargy and autonomic failure with a distinctive pattern of occurrence of Lewy bodies. Autonomic dysfunction such as sleep apnea, orthostatic hypotension, dysuria, and hypohidrosis predominated with lethargy, whereas parkinsonism was not apparent. Numerous Lewy bodies were widely evident microscopically in brainstem nuclei and the intermediolateral cell columns of the spinal cord, as well as in the sympathetic ganglia, but were rare or absent in the cerebral cortex and other supratentorial structures. Marked neuronal loss was seen in the locus ceruleus, raphe nuclei, dorsal vagal nuclei, and intermediolateral cell columns, but neurons in the substantia nigra, other brain regions, and sympathetic ganglia appeared undiminished. This case represents a specific clinicopathologic form of Lewy body disease occurring predominantly in the brainstem, spinal cord, and sympathetic ganglia. |
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AbstractList | The authors report an autopsy case characterized by progressive lethargy and autonomic failure with a distinctive pattern of occurrence of Lewy bodies. Autonomic dysfunction such as sleep apnea, orthostatic hypotension, dysuria, and hypohidrosis predominated with lethargy, whereas parkinsonism was not apparent. Numerous Lewy bodies were widely evident microscopically in brainstem nuclei and the intermediolateral cell columns of the spinal cord, as well as in the sympathetic ganglia, but were rare or absent in the cerebral cortex and other supratentorial structures. Marked neuronal loss was seen in the locus ceruleus, raphe nuclei, dorsal vagal nuclei, and intermediolateral cell columns, but neurons in the substantia nigra, other brain regions, and sympathetic ganglia appeared undiminished. This case represents a specific clinicopathologic form of Lewy body disease occurring predominantly in the brainstem, spinal cord, and sympathetic ganglia. |
Author | Washimi, Y Yoshida, M Sobue, G Hishikawa, N Imamura, K Hashizume, Y Mabuchi, C Hirayama, M Koike, Y |
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Cites_doi | 10.1007/s004010050693 10.1212/WNL.44.11.2060 10.1016/0022-510X(80)90064-7 10.1159/000114674 10.1136/jnnp.57.6.745 10.1001/archneur.1970.00480210017002 10.1001/archneur.1971.00480360037004 10.1136/jnnp.39.11.1092 10.1212/WNL.47.5.1113 10.1093/brain/95.3.457 10.1212/WNL.45.4.709 |
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SubjectTerms | Autonomic Nervous System - physiopathology Autonomic Nervous System Diseases - etiology Autonomic Nervous System Diseases - physiopathology Brain Stem - pathology Humans Lewy Body Disease - complications Lewy Body Disease - pathology Lewy Body Disease - physiopathology Male Middle Aged Sleep Stages |
Title | Brainstem-type Lewy body disease presenting with progressive autonomic failure and lethargy |
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