Low absolute bioavailability of oral naloxone in healthy subjects

• Published in: International journal of clinical pharmacology and therapeutics Vol. 50; no. 5; p. 360
• Main Authors: Smith, Kevin, Hopp, Michael, Mundin, Gill, Bond, Simon, Bailey, Paul, Woodward, Jo, Bell, David
• Format: Journal Article
• Language: English
• Published: Germany 01.05.2012
• Subjects: Administration, Oral; Adolescent; Adult; Biological Availability; Cross-Over Studies; Dose-Response Relationship, Drug; Humans; Male; Middle Aged; Naloxone - administration & dosage; Naloxone - adverse effects; Naloxone - pharmacokinetics; Narcotic Antagonists - pharmacokinetics; Oxycodone - administration & dosage

To determine the absolute bioavailability of naloxone from oral doses ranging from 5 mg to 120 mg. In this open-label study, 28 healthy subjects received naloxone 1 mg (0.4 mg/ml) as an intravenous infusion (reference treatment), and the following oral doses as prolonged release (PR) naloxone tablet...