Effects of exposure to different frequencies of electromagnetic fields on long-term potentiation in rat hippocampal CA1 region through intracellular Ca2+ concentration
Long-term potentiation (LTP) in the Schaffer-CA1 region of the hippocampus is closely related to learning and memory. Magnetic stimulation, as an effective physical means of regulating synaptic plasticity, has received widespread attention. However, research on the mechanism of the effect of differe...
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| Published in | AIP advances Vol. 14; no. 8; pp. 085120 - 085120-8 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
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American Institute of Physics
01.08.2024
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| Abstract | Long-term potentiation (LTP) in the Schaffer-CA1 region of the hippocampus is closely related to learning and memory. Magnetic stimulation, as an effective physical means of regulating synaptic plasticity, has received widespread attention. However, research on the mechanism of the effect of different frequencies of magnetic fields (MFs) on LTP is relatively scarce. This article focuses on Ca2+, Na+, K+, NMDA receptors, and AMPA receptors that play important roles in the process of MF regulation of LTP. A combined electrophysiological and pharmacological approach was used to identify Ca2+ as a key factor in the modulation of LTP by MFs of different frequencies. Subsequently, further experiments revealed that low levels of intracellular Ca2+ concentration ([Ca2+]i) intensified the inhibition of low-frequency MFs on LTP, while high levels of [Ca2+]i enhanced the promotion effect of high-frequency MFs on LTP, indicating a positive correlation between [Ca2+]i levels and MF regulation of LTP levels. The research results of this article may help explore the deeper relationship between different frequencies of MFs and synaptic plasticity, and they also have a certain reference value for magnetic stimulation therapy in the treatment of neurological diseases related to LTP injury or learning and memory deficits. |
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| AbstractList | Long-term potentiation (LTP) in the Schaffer-CA1 region of the hippocampus is closely related to learning and memory. Magnetic stimulation, as an effective physical means of regulating synaptic plasticity, has received widespread attention. However, research on the mechanism of the effect of different frequencies of magnetic fields (MFs) on LTP is relatively scarce. This article focuses on Ca2+, Na+, K+, NMDA receptors, and AMPA receptors that play important roles in the process of MF regulation of LTP. A combined electrophysiological and pharmacological approach was used to identify Ca2+ as a key factor in the modulation of LTP by MFs of different frequencies. Subsequently, further experiments revealed that low levels of intracellular Ca2+ concentration ([Ca2+]i) intensified the inhibition of low-frequency MFs on LTP, while high levels of [Ca2+]i enhanced the promotion effect of high-frequency MFs on LTP, indicating a positive correlation between [Ca2+]i levels and MF regulation of LTP levels. The research results of this article may help explore the deeper relationship between different frequencies of MFs and synaptic plasticity, and they also have a certain reference value for magnetic stimulation therapy in the treatment of neurological diseases related to LTP injury or learning and memory deficits. |
| Author | Song, Rujuan Zheng, Yu Dong, Lei Chen, Yazhou Wei, Shengjie |
| Author_xml | – sequence: 1 givenname: Yu surname: Zheng fullname: Zheng, Yu organization: School of Life Sciences, Tiangong University – sequence: 2 givenname: Rujuan surname: Song fullname: Song, Rujuan organization: School of Life Sciences, Tiangong University – sequence: 3 givenname: Shengjie surname: Wei fullname: Wei, Shengjie organization: School of Life Sciences, Tiangong University – sequence: 4 givenname: Lei surname: Dong fullname: Dong, Lei organization: 3Army Engineering University, National Key Laboratory Electromagnetic Environmental Effects, Shijiazhuang Campus, Shijiazhuang , Hebei, China – sequence: 5 givenname: Yazhou surname: Chen fullname: Chen, Yazhou organization: 3Army Engineering University, National Key Laboratory Electromagnetic Environmental Effects, Shijiazhuang Campus, Shijiazhuang , Hebei, China |
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| Cites_doi | 10.1007/BF02556612 10.1098/rstb.2002.1226 10.1111/acel.13008 10.1038/srep21774 10.1038/nn0901-917 10.1146/annurev.ne.10.030187.001023 10.1002/bem.22437 10.3109/09553002.2014.995382 10.1080/09553002.2022.2094022 10.1021/acschemneuro.1c00500 10.1016/s0896-6273(00)00129-x 10.1152/jn.00217.2005 10.1080/09553002.2016.1259671 10.1038/s41380-021-01332-6 10.1016/0896-6273(92)90227-5 10.1146/annurev.neuro.25.112701.142758 10.1109/ACCESS.2019.2947690 10.1016/j.bbrc.2019.07.085 10.1126/science.285.5435.1870 10.1126/science.1102026 10.1016/j.neuron.2004.09.012 10.1016/0959-4388(95)80045-X 10.3109/15368378.2014.881744 10.1016/0959-4388(93)90210-P 10.1126/science.aas9204 10.1038/361031a0 10.1016/j.neuropharm.2022.109271 |
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| Snippet | Long-term potentiation (LTP) in the Schaffer-CA1 region of the hippocampus is closely related to learning and memory. Magnetic stimulation, as an effective... |
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| SubjectTerms | Calcium ions Electromagnetic fields Learning Neurological diseases Receptors Stimulation |
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| Title | Effects of exposure to different frequencies of electromagnetic fields on long-term potentiation in rat hippocampal CA1 region through intracellular Ca2+ concentration |
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