Mechanistic update of Trisenox in blood cancer

• Published in: Current research in pharmacology and drug discovery Vol. 5; p. 100166
• Main Authors: Ananta, Benerjee, Swati, Tchounwou, Paul B, Kumar, Sanjay
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier 2023
• Subjects: APL cells; PML-RARα; Trisenox; Trisenox; PML-RARα; APL cells

Acute promyelocytic leukemia (APL)/blood cancer is M3 type of acute myeloid leukemia (AML) formed inside bone marrow through chromosomal translocation mutation usually between chromosome 15 & 17. It accounts around 10% cases of AML worldwide. Trisenox (TX/ATO) is used in chemotherapy for treatme...