Efficacy of long‐acting injectable versus oral antipsychotic drugs in early psychosis: A systematic review and meta‐analysis

• Published in: Early intervention in psychiatry Vol. 16; no. 6; pp. 589 - 599
• Main Authors: Lian, Lulu, Kim, David D., Procyshyn, Ric M., Fredrikson, Diane H., Cázares, Diana, Honer, William G., Barr, Alasdair M.
• Format: Journal Article
• Language: English
• Published: Melbourne Wiley Publishing Asia Pty Ltd 01.06.2022; Wiley Subscription Services, Inc
• Subjects: Administration, Oral; antipsychotic; Antipsychotic Agents - therapeutic use; Antipsychotics; Delayed-Action Preparations - therapeutic use; Drugs; Effectiveness; Hospitalization; Humans; long‐acting injectable; Meta-analysis; oral antipsychotic; Psychosis; Psychotic Disorders - drug therapy; Psychotropic drugs; Recurrence; Schizophrenia; meta-analysis; oral antipsychotic; long-acting injectable; antipsychotic; schizophrenia; psychosis

Aim Long‐acting injectable antipsychotic drugs (LAIs) are often used as an alternative to oral antipsychotics (OAPs) in individuals with psychosis who demonstrate poor medication adherence. Previous meta‐analyses have found mixed results on the efficacy of LAIs, compared to OAPs, in patients with ps...