Time of day affects MrgD-dependent modulation of cardiomyocyte contractility

• Published in: American Journal of Physiology: Cell Physiology Vol. 327; no. 4; pp. C1143 - C1149
• Main Authors: Monteiro, André L. L., Eliezeck, Marcos, Scalzo, Sérgio R. A., Silva, Mário Morais, Sanches, Bruno, Ferreira, Katyana K. S., Poletini, Maristela O., Peliciari-Garcia, Rodrigo A., Cau, Stêfany B. A., Souza Santos, Robson A., Guatimosim, Silvia
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 01.10.2024
• Subjects: Angiotensin; Angiotensin II; Animals; Arginine; Cardiomyocytes; Cells, Cultured; Circadian Rhythm - drug effects; Circadian Rhythm - physiology; Circadian rhythms; Homeostasis; Male; Mice; Mice, Inbred C57BL; Muscle contraction; Myocardial Contraction - drug effects; Myocardial Contraction - physiology; Myocytes; Myocytes, Cardiac - drug effects; Myocytes, Cardiac - metabolism; NG-Nitroarginine methyl ester; Nitric oxide; Nitric Oxide - metabolism; Nitric-oxide synthase; Oligopeptides - pharmacology; Peptides; Receptors, G-Protein-Coupled - agonists; Receptors, G-Protein-Coupled - metabolism; Receptors, Neuropeptide - agonists; Receptors, Neuropeptide - antagonists & inhibitors; Receptors, Neuropeptide - metabolism; Renin; Renin-Angiotensin System - drug effects; Renin-Angiotensin System - physiology; Structure-function relationships; nitric oxide; light/dark cycle; heart; alamandine; fractional shortening

Alamandine, a member of the renin-angiotensin system, serves critical roles in cardioprotection, including the modulation of cardiomyocyte contractility. Whether this effect varies along the day is unknown. Our results provide evidence that alamandine via receptor MrgD exerts opposing actions on car...