Use of human vessels and human vascular smooth muscle cells in pharmacology
Relatively limited information is available regarding the mechanisms controlling vasomotricity in human vessels. Isolated vessels obtained from patients undergoing surgery were used to characterize the role of endothelial factors and to study coupling mechanisms between receptors, intracellular calc...
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Published in | Cell biology and toxicology Vol. 12; no. 4-6; p. 223 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
Netherlands
01.12.1996
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Subjects | |
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Abstract | Relatively limited information is available regarding the mechanisms controlling vasomotricity in human vessels. Isolated vessels obtained from patients undergoing surgery were used to characterize the role of endothelial factors and to study coupling mechanisms between receptors, intracellular calcium, and contraction. However, these investigations are limited by the availability of tissues and many uncontrolled factors. Cultured human vascular cells were also used, but these cells rapidly lose at least some of their differentiated characters. Recently, a human blood vessel equivalent was constructed in vitro from cultured cells, using tissue engineering. This technique allowed us to obtain vessel equivalents containing intima, media, and adventitia layers or tubular media layer only. Contraction and rises in intracellular calcium produced by agonists were studied, indicating that such human vessel equivalents may provide valuable models for pharmacological studies. |
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AbstractList | Relatively limited information is available regarding the mechanisms controlling vasomotricity in human vessels. Isolated vessels obtained from patients undergoing surgery were used to characterize the role of endothelial factors and to study coupling mechanisms between receptors, intracellular calcium, and contraction. However, these investigations are limited by the availability of tissues and many uncontrolled factors. Cultured human vascular cells were also used, but these cells rapidly lose at least some of their differentiated characters. Recently, a human blood vessel equivalent was constructed in vitro from cultured cells, using tissue engineering. This technique allowed us to obtain vessel equivalents containing intima, media, and adventitia layers or tubular media layer only. Contraction and rises in intracellular calcium produced by agonists were studied, indicating that such human vessel equivalents may provide valuable models for pharmacological studies. |
Author | Germain, L Andriantsitohaina, R Stoclet, J C L'heureux, N Martinez, C Auger, F |
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BackLink | https://www.ncbi.nlm.nih.gov/pubmed/9034612$$D View this record in MEDLINE/PubMed |
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References | 8445745 - J Vasc Surg. 1993 Mar;17(3):499-509 1846268 - Am J Physiol. 1991 Jan;260(1 Pt 1):C151-8 7489799 - Eur Respir J. 1995 Aug;8(8):1328-32 8119307 - Eur J Pharmacol. 1993 Nov 30;250(1):103-7 2536016 - J Biol Chem. 1989 Jan 15;264(2):1146-55 108688 - Physiol Rev. 1979 Jan;59(1):1-61 2264075 - Stroke. 1990 Dec;21(12):1689-93 1425951 - Eur J Pharmacol. 1992 Aug 25;219(2):225-33 |
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SubjectTerms | Calcium - metabolism Cells, Cultured Humans Muscle Contraction - physiology Muscle, Smooth, Vascular - physiology Pharmacology - methods Umbilical Veins - cytology |
Title | Use of human vessels and human vascular smooth muscle cells in pharmacology |
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