In search of a function for tetrahydrobiopterin in the biosynthesis of nitric oxide

• Published in: Naunyn-Schmiedeberg's archives of pharmacology Vol. 351; no. 5; p. 453
• Main Authors: Mayer, B, Werner, E R
• Format: Journal Article
• Language: English
• Published: Germany 01.05.1995
• Subjects: Amino Acid Oxidoreductases - metabolism; Animals; Biopterins - analogs & derivatives; Biopterins - biosynthesis; Biopterins - metabolism; Biopterins - physiology; Feedback; Nitric Oxide - biosynthesis; Nitric Oxide Synthase

(6R)-5,6,7,8-Tetrahydro-L-biopterin(H4biopterin) is well known as a cofactor of enzymes that hydroxylate aromatic amino acids. More recent work has revealed an essential role of H4biopterin in the biosynthesis of nitric oxide (NO), an intercellular messenger molecule synthesized from L-arginine by d...