Hypothalamo-pituitary effects of RU486: inhibition of progesterone-induced hyperprolactinaemia

• Published in: Human reproduction (Oxford) Vol. 9 Suppl 1; p. 63
• Main Authors: Williams, R F, Gordon, K, Fung, H, Kolm, P, Hodgen, G D
• Format: Journal Article
• Language: English
• Published: England 01.06.1994
• Subjects: Animals; Estradiol - blood; Estradiol - toxicity; Female; Hyperprolactinemia - chemically induced; Hyperprolactinemia - prevention & control; Hypothalamo-Hypophyseal System - drug effects; Macaca fascicularis; Mifepristone - pharmacology; Progesterone - antagonists & inhibitors; Progesterone - blood; Progesterone - toxicity; Progestational Hormones; Progesterone > analysis; Pituitary Hormones; Estrogens; Biology; Hormones; Hypothalamus; Endocrine System; Central Nervous System; Clinical Research; Research Report; Physiology; Estradiol > analysis; Hormone Antagonists; Prolactin > analysis; Pituitary Gland; Animals, Laboratory; Ru-486 > administraction and dosage

Monkeys given oestrogen priming at physiological levels for at least 1 week become hyperprolactinaemic upon the addition of physiological progesterone administration. Here, using RU486, we test whether that this oestrogen/progestin-induced hyperprolactinaemia results from classical progesterone acti...